Immune- and Inflammatory-Mediated Central Nervous System Syndromes Mark P. Gorman The central role of the immune system in several pediatric central nervous system (CNS) disorders has been increasingly…
Principles of Inborn Errors of Metabolism Jean-Marie Saudubray and Joe T. R. Clarke Over 400 human diseases that are due to inborn errors of metabolism are now recognized,…
Disorders of Heme Biosynthesis: The Porphyrias Robert J. Desnick The porphyrias are a group of inherited and acquired metabolic disorders, each resulting from the deficient activity of a…
Disorders of Bile Acid Synthesis Peter T. Clayton METABOLIC PATHWAYS The major bile acids produced in the liver are the taurine and glycine conjugates (amidates) of chenodeoxycholic acid…
Disorders of Lipid and Lipoprotein Metabolism Peter O. Kwiterovich Jr. Disorders of lipid and lipoprotein metabolism are characterized by dyslipidemia, which is defined as either elevated or low…
Acquired Coagulation Disorders Guy Young Many hemorrhagic disorders in children are caused by genetic defects, but there are also a number of important acquired conditions that can lead…
Disorders of the Epidermis Kristen E. Holland Primary skin diseases that principally affect the epidermis may be categorized as either a dermatitis or a papulosquamous disorder. Dermatitis commonly…
Neonatal Dermatology Sheila S. Galbraith NEONATAL SKIN DEVELOPMENT AND PHYSIOLOGY The skin of a newborn infant differs from adult skin in several ways that place infants at increased…
Antibacterial Therapy David K. Hong and Charles G. Prober The first antibiotic to be discovered was penicillin, a natural product of Penicillium mold. Innumerable microbial products have been…
Diagnosis and Management of Thrombosis Janna M. Journeycake and Anthony K. C. Chan Thrombosis, defined as excessive clotting, has three main causes: reduced blood flow (stasis), increase in…
