Epstein-Barr Virus Mononucleosis W. Garrett Hunt and Michael T. Brady The Epstein-Barr virus (EBV) is recognized as the major cause of heterophil-positive and heterophil-negative infectious mononucleosis. Manifestations of…
Cranial Developmental Abnormalities Omar Khwaja The central nervous system (CNS) is the most complex organ in the human body comprising a highly organized anatomic scaffold of billions of…
Varicella-Zoster Virus Infections Sophie Hambleton The human α-herpesvirus, varicella-zoster virus (VZV), is a highly successful pathogen that has coevolved with its human hosts over millennia. The majority of…
Disorders of Tyrosine Metabolism Bernd Christian Schwahn The five known inherited disorders in the metabolism of the nonessential amino acid tyrosine are each very rare and present in…
Antifungal Therapy Patricia M. Flynn Antifungal agents are available in systemic and topical formulations, and some are available in both forms. Topical antifungal agents, because they are poorly…
Anatomic Disorders of the Esophagus Dave R. Lal Congenital atresia of the esophagus and tracheoesophageal fistula occur in 1 of every 2500 to 3000 live births. Other congenital…
Enterovirus Infections José R. Romero The Enteroviruses constitute a genus within the Picornaviridae family of viruses. As their family name implies, these viral agents are small (ie, “pico”),…
Disorders of the Upper Extremity Marybeth Ezaki This brief section is meant to cover the upper extremity conditions that are commonly seen or are important for timely diagnoses…
Rhabdomyosarcoma Douglas S. Hawkins and Frederic G. Barr Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, representing approximately 5% of all cancers among children and…
Evaluation of the Infant and Child with Liver Disease Robert H. Squires Jr. Evidence of liver disease in children may take different forms. Physical findings are the most…
