Hyperthyroidism Delbert A. Fisher JUVENILE GRAVES DISEASE Graves disease is a multisystem autoimmune disease involving hyperthyroidism, eye manifestations, and dermopathy.1-12In children, in contrast to adults, the latter manifestation…
Disorders of Metabolism of Neurotransmitter Amino Acids Jaak Jaeken INTRODUCTION This chapter deals with defects in the catabolism of gamma-aminobutyric acid (GABA), with defects in receptors of neurotransmitters…
Interstitial Lung Disease Jennifer A. Rama and Leland L. Fan Childhood interstitial lung disease (ChILD) comprises a heterogeneous group of chronic pulmonary disorders, characterized by diffuse parenchymal infiltrates…
Allergic and Eosinophilic Gastroenteropathies B U.K. Li Allergic and eosinophilic disorders of the gastrointestinal (GI) tract have in common an infiltrate of eosinophils into the wall of the…
Congenital Anomalies of the Anorectum Casey M. Calkins and Manu R. Sood The spectrum of anorectal malformations (ARMs) ranges from anal stenosis to persistent cloaca. The term imperforate…
Hodgkin Lymphoma Melissa M. Hudson and Tanya M. Trippett Hodgkin lymphoma is a hematopoietic malignancy with unique epidemiologic features that vary depending on the geographic region of the…
Pneumococcal Infections Sandra R. Arnold and P. Joan Chesney Streptococcus pneumoniae, Staphylococcus aureus, and group A Streptococcus pyogenes are the three most important bacterial pathogens causing infections in…
Trypanosomiases Eduardo Ortega-Barria AFRICAN TRYPANOSOMIASIS African trypanosomiasis (sleeping sickness) is a parasitic disease transmitted by tsetse flies of the genus Glossina and caused by a group of parasites…
Adrenal Insufficiency Walter L. Miller Signs and symptoms of adrenal insufficiency are listed in Table 534-1. Most patients with chronic adrenal insufficiency have weakness, fatigue, anorexia, weight loss,…
Cytomegalovirus Mark R. Schleiss Cytomegalovirus (CMV) is one of the family of eight human herpesviruses, designated as human herpesvirus type 5 (HHV-5) (Table 309-1). Taxonomically, it is referred…
