Disorders of Pentose Phosphate Pathway Priya S. Kishnani and Yuan-Tsong Chen PHOSPHOENOLPYRUVATE CARBOXYKINASE (PEPCK) DEFICIENCY PEPCK is a key enzyme in gluconeogenesis. It catalyzes the conversion of oxaloacetate…
Intraventricular Hemorrhage Henrietta S. Bada Neonatal germinal matrix hemorrhage/intraventricular hemorrhage (GMH/IVH) remains a common form of intracranial hemorrhage in preterm infants. It is an important cause of long-term…
Brain Abnormalities and Injuries Seetha Shankaran and C. Michael Cotton Neonatal encephalopathy is a clinically defined syndrome of disturbed neurological function in the early postnatal days of life…
Disorders of Ketolysis Stephen I. Goodman Ketolysis involves esterification of acetylaceto-nate (AcAc) to AcAcCoA by succinyl-CoA: 3-oxoacid transferase (SCOT) and involves hydrolysis of AcAcCoA by 3-ketothiolase to form…
Blastocystis hominis Maria Jevitz Patterson Continued controversy exists about Blastocystis hominis. Long considered a protozoan of worldwide distribution, most likely an amoeba, this strict anaerobe has been classified…
Disorders of Energy Metabolism Juan M. Pascual and Salvatore DiMauro Surprisingly, the number of energy metabolism disorders compatible with life is still expanding, and their manifestations are reaching…
Hematologic Abnormalities and Jaundice Henry C. Lee and Ashima Madan RED BLOOD CELL DISORDERS Hematologic problems arise frequently in the newborn period.1 This section is focused on disorders…
Reproductive Growth and Development in the Male Adolescent David J. Breland and Mark L. Rubinstein TESTIS Testicular growth and maturation are largely influenced by testosterone, which is produced…
Acute Fever without a Focus Steven Black Fever is defined as a regulated rise in core body temperature. That is, as distinct from hyper-thermia, it is a measured…
Insect Allergy Maria Garcia-Lloret Insect stings and bites, including toxins are discussed further in Chapter 120. EPIDEMIOLOGY Up to 3% of the general population has bee sting allergy.1…
