. Diagnostic Approach to Renal Disease
Diagnostic Approach to Renal Disease John W. Foreman CLINICAL PRESENTATION OF RENAL DISEASE The symptoms and signs of childhood renal disorders vary widely. Diagnostic clues are provided from…
. Diagnostic Testing in Rheumatology
Diagnostic Testing in Rheumatology Peter A. Nigrovic Laboratory and imaging studies rarely establish a definitive diagnosis of rheumatologic diseases in children. The prevalence of rheumatic diseases in childhood…
. Disorders of Cholesterol Synthesis
Disorders of Cholesterol Synthesis Peter T. Clayton The isoprenoid synthesis pathway (Fig. 164-1) leads to the synthesis of cholesterol, haem A, ubiquinone, dolichol, farnesyl-pyrophosphate, and geranylgeranyl-pyrophosphate. When cholesterol…
. Autoinflammatory Disorders
Autoinflammatory Disorders Philip J. Hashkes Autoinflammatory syndromes, formerly known as periodic fever syndromes, are defined as recurrent attacks of often unprovoked systemic inflammation that are related to a…
. Disorders of Sulfur-Containing Amino Acid Metabolism
Disorders of Sulfur-Containing Amino Acid Metabolism Bernd Christian Schwahn Sulfur-containing amino acids have various roles: They mediate the transfer of methyl groups for virtually all transmethylation reactions; they…
. Hospice and Palliative Care
Hospice and Palliative Care Julie Hauer, Barbara L. Jones, and Joanne Wolfe Palliative care is a model of interdisciplinary care that seeks to improve the quality of life…
. Gastroesophageal Reflux and Other Causes of Esophageal Inflammation
Gastroesophageal Reflux and Other Causes of Esophageal Inflammation Colin D. Rudolph GASTROESOPHAGEAL REFLUX Gastroesophageal reflux (GER) is the spontaneous passage of gastric contents into the esophagus. It is…
. Leukoencephalopathies
Leukoencephalopathies Mark P. Gorman Leukoencephalopathies comprise a clinical and radiographic heterogeneous group of disorders. All these disorders share the common features of neurologic dysfunction and preferential involvement of…
. Tools for Diagnosis and Management of Respiratory Disease
Tools for Diagnosis and Management of Respiratory Disease Beverley Newman and Geoffrey Kurland Viewing the pediatric chest and lungs, whether by radiographic or bronchoscopic means, is often central…
. Sexually Transmitted Infections
Sexually Transmitted Infections Loris Y. Hwang, Anna-Barbara Moscicki, and Mary-Ann Shafer Currently, substantial numbers of adolescents engage in sexual intercourse: 34% have experienced their sexual debut by ninth…
