. Neonate and Infant with Cardiovascular Disease
Neonate and Infant with Cardiovascular Disease David F. Teitel OVERVIEW Although there are over 7000 different congenital cardiac defects,1 there are only a very few ways that a…
. Clinical Approach to Neurologic Disease
Clinical Approach to Neurologic Disease Maitreyi Mazumdar HOW TO USE THIS SECTION This introductory section on pediatric neurology provides a clinically oriented guide to the evaluation of a…
. The Spleen and Lymph Nodes
The Spleen and Lymph Nodes Shelley E. Crary The spleen is the largest lymphoid organ in the body and plays a vital role in hematologic functions as well…
. Fluid, Electrolyte, and Acid-Base Disorders
Fluid, Electrolyte, and Acid-Base Disorders Manjula Gowrishankar The composition of body fluids, metabolic requirements, and ability to adapt to change differs in infants and children compared to adults….
. Diagnostic Approach to Renal Disease
Diagnostic Approach to Renal Disease John W. Foreman CLINICAL PRESENTATION OF RENAL DISEASE The symptoms and signs of childhood renal disorders vary widely. Diagnostic clues are provided from…
. Diagnostic Testing in Rheumatology
Diagnostic Testing in Rheumatology Peter A. Nigrovic Laboratory and imaging studies rarely establish a definitive diagnosis of rheumatologic diseases in children. The prevalence of rheumatic diseases in childhood…
. Disorders of Cholesterol Synthesis
Disorders of Cholesterol Synthesis Peter T. Clayton The isoprenoid synthesis pathway (Fig. 164-1) leads to the synthesis of cholesterol, haem A, ubiquinone, dolichol, farnesyl-pyrophosphate, and geranylgeranyl-pyrophosphate. When cholesterol…
. Autoinflammatory Disorders
Autoinflammatory Disorders Philip J. Hashkes Autoinflammatory syndromes, formerly known as periodic fever syndromes, are defined as recurrent attacks of often unprovoked systemic inflammation that are related to a…
. Disorders of Sulfur-Containing Amino Acid Metabolism
Disorders of Sulfur-Containing Amino Acid Metabolism Bernd Christian Schwahn Sulfur-containing amino acids have various roles: They mediate the transfer of methyl groups for virtually all transmethylation reactions; they…
. Hospice and Palliative Care
Hospice and Palliative Care Julie Hauer, Barbara L. Jones, and Joanne Wolfe Palliative care is a model of interdisciplinary care that seeks to improve the quality of life…
