Pharmacologic Therapies II: Inhaled Nitric Oxide
Endogenous nitric oxide (NO) is important for the regulation of vascular tone. The enzyme NO synthase generates NO from L-arginine. NO then activates guanyl cyclase and increases the production of…
PEDIATRICS
Pharmacologic Therapies III: Cardiovascular Therapy and Persistent Pulmonary Hypertension of the Newborn
Introduction Hemodynamic problems are frequent in infants undergoing neonatal intensive care. The evaluation and treatment of such problems must take into account the developmental physiology of the neonatal cardiovascular system,…
Intraoperative Management of the Neonate
The neonatal patient requiring surgery presents a unique challenge in the delivery of safe and effective airway management, ventilation, sedation, and anesthesia. The physiology of the neonate is unique and…
Neonatal Respiratory Care in Resource-Limited Countries
Acknowledgment We would like to acknowledge Dr. Dharmapuri Vidyasagar for his contributions in the earlier edition of this chapter. The first chapter in this book describes the historical origins of…
Transport of the Ventilated Infant
Acknowledgment We would like to acknowledge Dr. Kristen Melton and Dr. Gary Pettett for their contributions in the earlier edition of this chapter. Important Role of the Transport Team The…
Management of the Infant with Bronchopulmonary Dysplasia
Introduction Infant chronic lung disease, or bronchopulmonary dysplasia (BPD), is a debilitating lung disease that occurs in premature infants. Since the nineteen seventies, advances in neonatal intensive care have led…
Pharmacologic Therapies IV: Other Medications
Introduction Pharmacologic agents are often used during mechanical ventilation of newborn infants to achieve various therapeutic goals including sedation and analgesia, neuromuscular paralysis, maintenance of fluid balance, and treatment of…
Delivery Room Stabilization, and Respiratory Support
Introduction Rapid and complex physiologic changes occur around the time of birth. The keys to a successful transition are the clearance of lung fluid and the establishment of a functional…
Respiratory Care of the Newborn
Respiratory care encompasses a set of practices, usually implemented by a multidisciplinary team (physician, respiratory therapist, nurse), to ensure the optimal delivery of respiratory support to newborn infants with respiratory…
Description of Available Devices
Introduction to Ventilators A ventilator is defined as an automatic machine designed to provide all or part of the work required to generate enough ventilation to satisfy the body’s respiratory…
