. Approach to the Cyanotic Infant
Approach to the Cyanotic Infant Robin H. Steinhorn ASSESSMENT Cyanosis, or bluish discoloration of the skin, is derived from the Greek word kuaneos, meaning dark blue. Cyanosis is…
. Primary Immunodeficiencies
Primary Immunodeficiencies Talal A. Chatila Primary immunodeficiency diseases result from genetic defects affecting the development and/or the function of immune system components.1-5 They frequently manifest soon after birth,…
. Epidemiology of Childhood Cancer
Epidemiology of Childhood Cancer Louise Parker CANCER IS AN IMPORTANT CAUSE OF MORTALITY Childhood cancer is diagnosed in around 1 in 600 children under age 15 years. Nonetheless,…
. Head and Neck Masses
Head and Neck Masses David E. Tunkel and Jonathan A. Perkins Head and neck masses commonly occur in young children, and the differential diagnosis for such masses is…
. Clostridial Infections
Clostridial Infections Jose Zayas and Mobeen H. Rathore CLOSTRIDIUM DIFFICILE Clostridium difficile is a spore-forming, obligate anaerobic, Gram-positive bacillus, which can spread via the fecal-oral route. The most…
. Pain Management and Sedation
Pain Management and Sedation Alan Farrow-Gillespie “Although the world is full of suffering, it is also full of the overcoming of it.” —Helen Keller, 1880–1968. The word…
. Arboviruses
Arboviruses Jason Brophy and Elizabeth Lee Ford-Jones Arboviruses (or arthropod-borne viruses) are a heterogeneous group of viruses that share the same usual route of entry into humans: via…
. Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease
Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease Earl D. Silverman SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) Systemic lupus erythematosus (SLE) represents the prototype of a…
. Peroxisomal Disorders
Peroxisomal Disorders David Valle, Gerald V. Raymond, and Stephen J. Gould PEROXISOME BIOLOGY AND METABOLISM Peroxisomes are single membrane-bound or-ganelles present in all cells except for erythro-cytes. In…
