KEY POINTS 1. Retinopathy of prematurity (ROP) is a disease characterized by altered vascularization of the immature retina of premature infants and is common cause of reduced vision in the…

KEY POINTS 1. Acute kidney injury (AKI), previously referred to as “acute renal failure”, is defined by an abrupt change in the glomerular filtration rate with rising serum creatinine levels…

KEY POINTS 1. Neonatal encephalopathy is an alteration in consciousness or neurologic exam in newborn infants. Hypoxic-ischemic encephalopathy accounts for nearly 50% of all cases. 2. Clinical presentation depends on…

KEY POINTS 1. In the United States an infant is born every 15 minutes who will develop symptoms of neonatal abstinence syndrome (NAS); each year, about 32,000 infants are estimated to…

KEY POINTS 1. Congenital heart diseases (CHDs) are an important cause of morbidity and mortality in young infants. These malformations account for approximately 300,000 deaths yearly. 2. Cardiac septal defects…

KEY POINTS 1. Spina bifida is the most common nonlethal birth defect of the central nervous system and occurs when the vertebral column fails to close, resulting in neurologic impacts…

KEY POINTS 1. Seizures are very common in the neonatal period and constitute a neurologic emergency. 2. Specific aspects of the physiology of the developing brain make it highly susceptible…

KEY POINTS 1. Perinatal arterial ischemic stroke most often results from the convergence of multiple stroke risk factors specific to the perinatal period and has a low risk of recurrence….

KEY POINTS 1. Encephalopathy of prematurity reflects white and gray matter injury combined with neuronal-axonal abnormalities impacting preterm infants. 2. Key risk factors include hypotension and the need for inotropes,…

KEY POINTS 1. A healthy fetus has considerable aerobic and anaerobic reserves to successfully adapt to transient or mild hypoxia. Prolonged or repeated severe asphyxia results in failure of adaptation…