Drug Formulations
Drug Formulations Milap C. Nahata A continuing decline in the morbidity and mortality in the pediatric population can be attributed, in part, to the availability of effective drugs for preventing…
PEDIATRICS
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring Alexander A. Vinks Philip D. Walson Introduction The simplest way to identify interindividual variability in drug response is to objectively measure the degree of effect and then…
Ethics of Drug Research in Pediatric Populations
Ethics of Drug Research in Pediatric Populations Bruce A. Russell Sanford N. Cohen Virginia Delaney-Black Why Research on Children is Needed The majority of pharmacologic agents and pharmaceutical preparations currently…
Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations
Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations Steven Hirschfeld Brief History of Research Involving Children Children have been utilized to test new therapies for thousands of…
Adherence with Pediatric Medication Regimens
Adherence with Pediatric Medication Regimens Hakan Ergün Daniel A.C. Frattarelli Doreen Matsui Introduction In pharmacotherapy, the terms “compliance” and “adherence” are often used interchangeably, although the latter term is preferred…
Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics J. Steven Leeder Introduction It is readily accepted that genetic factors play an important role in influencing a child’s potential physical characteristics such as height, weight,…
Drug Metabolism and Disposition in Infants and Children
Drug Metabolism and Disposition in Infants and Children Anders Rane The new regulatory framework for development of drugs for children has promoted the interest in pediatric pharmacology and left behind…
Clinical Pharmacokinetics in Infants and Children
Clinical Pharmacokinetics in Infants and Children Edmund V. Capparelli Introduction Considerable growth has occurred in the number of new chemical and biologic treatments during the last 25 years. Appropriate use…
Drug Action and Therapy in the Infant and Child
Drug Action and Therapy in the Infant and Child Ralph E. Kauffman Infancy and childhood extend from 2 months of age to the onset of puberty, which typically occurs at…
Introduction and Historical Perspectives
Introduction and Historical Perspectives Sumner J. Yaffe Jacob V. Aranda The following is an excerpt from the second edition of this book: The past several decades have witnessed a revolution…
