Pharmacologic Treatment of Neonatal Apnea
Pharmacologic Treatment of Neonatal Apnea Girija Natarajan Jose Maria Lopes J. V. Aranda Methylxanthines Since the initial report in 1973 of a decrease in the frequency of apneic episodes in…
PEDIATRICS
Drugs and Lung Development
Drugs and Lung Development Alan H. Jobe John P. Newnham Lung development is a target for drug therapy only within the context of prematurity. Corticosteroids are standard of care for…
Drugs for Hyperbilirubinemia
Drugs for Hyperbilirubinemia David K. Stevenson Ronald J. Wong Susan R. Hintz Hendrik J. Vreman Introduction Hyperbilirubinemia is a natural and essentially ubiquitous transitional phenomenon among human newborns. Approximately 60%…
The Excretion of Drugs and Chemicals in Human Milk
The Excretion of Drugs and Chemicals in Human Milk Cheston M. Berlin Jr. Introduction During the 1960s and the early 1970s, the incidence of breastfeeding reached a nadir; in 1972…
Renal Function and Excretion of Drugs in the Newborn
Renal Function and Excretion of Drugs in the Newborn John N. van den Anker Karel Allegaert A thorough understanding of the developmental changes in neonatal renal function is needed to…
Perinatal Origins of Adult Defects in Drug Metabolism
Perinatal Origins of Adult Defects in Drug Metabolism Bernard H. Shapiro One of the hot topics in medicine today is the so-called fetal origins of adult diseases. This intriguing topic…
Principles of Neonatal Pharmacology
Principles of Neonatal Pharmacology Jeffrey L. Blumer Michael D. Reed Introduction The history of drug therapy is replete with examples of adverse reactions to drugs in children. Virtually all the…
Maternal Drug Intake and the Newborn
Maternal Drug Intake and the Newborn Nada Djokanovic Rada Boskovic Gideon Koren Introduction The use of prescription drugs during pregnancy has become a concern since the thalidomide tragedy. However, medication…
Biotransformation of Medications by Human Placenta
Biotransformation of Medications by Human Placenta Olga Zharikova Tatiana Nanovskaya Mahmoud S. Ahmed Introduction Human placenta is a tissue of fetal origin located at the interface between the maternal and…
Developmental Toxicology
Developmental Toxicology Donald R. Mattison Introduction The United States has made progress in maternal and infant health (1,2,3,4); infant mortality has fallen (Fig. 11.1) as a consequence of pediatric nutrition,…
