Ependymoma
Fig. 13.1 This MRI shows a very large posterior fossa ependymoma filling the fourth ventricle and extending into the left cerebellopontine angle through the foramen of Luschka (Reprinted from Teo…
Embryonal Brain Tumors
Fig. 12.1 CT and MR imaging of medulloblastoma.(a) Axial contrast-enhanced CT showing a hyperdense mass compressing the 4th ventricle (white arrow). Note the hydrocephalus with accompanying trans-ependymal flow (white arrow)….
Pediatric Neuro-Oncology in Countries with Limited Resources
Continent Countries included/submitted data PBCR included/submitted data Geographic coverage by continent (%) Population coverage in millions (%) Africa 5/14 5/16 31 8.8 (1 %) Asia 15/18 44/77 57 152.3 (4…
Palliative Care for Children with Brain Tumors
Medication Indication Route Initial dosage Maximum Frequency Dexamethasone Raised intracranial pressure, nausea and vomiting PO/NG, SC, IV 1–2 mg/kg (initial) 4–10 mg/dose Q6–12 h 0.25–0.5 mg/kg Ondansetron Nausea and vomiting…
Quality of Life
Characteristic Definition 1. Subjective QoL is an individual perception and the only reliable source for evaluation—it is the person itself 2. Phenomenological QoL is perceived. It is like a photograph,…
Neuropsychological Outcomes in Pediatric Brain Tumor Survivors
Fig. 24.1 Predictors of neuropsychological outcome in PBTS Neuropsychological Outcomes There is considerable heterogeneity in individual neuropsychological outcomes for PBTS given the variety of tumor types and/or treatments and associated…
Diffuse Intrinsic Pontine Glioma
Reference Classification system Epstein [2] Intrinsic Diffuse Focal Cervicomedullary Exophytic Anterolateral Posterolateral Disseminated Positive CSF cytology Positive myelography Choux et al. [3] Type I Diffuse Type II Intrinsic, focal Type…
Supportive Care
High level of emetic risk (>90 % frequency of emesis in absence of prophylaxis) Altretamine Dactinomycin Carboplatin Mechlorethamine Carmustine >250 mg/m2 Methotrexate ≥12 g/m2 Cisplatin Procarbazine (oral) Cyclophosphamide ≥1 g/m2…
High-Dose Chemotherapy/Stem Cell Transplantation (HDSCT)
© Springer Science+Business Media New York 2015Katrin Scheinemann and Eric Bouffet (eds.)Pediatric Neuro-oncology10.1007/978-1-4939-1541-5_21 21. High-Dose Chemotherapy/Stem Cell Transplantation (HDSCT) Victor Anthony Lewis1 and Shahrad Rod Rassekh2 (1) Department of Pediatrics, Alberta Children’s Hospital, Calgary, AB, Canada (2) Division of…
Targeted Therapies in Paediatric Brain Tumours
Study type Drug BSG Ependymoma Medulloblastoma/sPNET HGG LGG Other Total Outcome References Phase I Gefitinib 3 (2 SD) 1 4 2 SD [30] Phase I Lonafarnib 7 9 8 18 …
