Precancerous Lesions of Endometrial Serous Carcinomas
Fig. 8.1 Serous EIC in a glandular pattern and flat pattern Fig. 8.2 Serous EIC, glandular pattern: cytologic features – a given case may variably show severe pleomorphism, hobnail nuclei,…
Vulvar Intraepithelial Neoplasia
ISSVD 1976 ISSVD 1986 WHO 1994 ISSVD 2004 LASTa 2012 WHO 2014 Hyperplastic dystrophy with atypia, mild Vulvar intraepithelial neoplasia (VIN) I Mild dysplasia (VIN 1) – Low-grade squamous intraepithelial…
Precursors of Cervical Adenocarcinomas
Fig. 12.1 Usual-type adenocarcinoma of the cervix, composed of tall columnar cells with significant nuclear enlargement, elongation, stratification, and hyperchromasia. The cytoplasm is rather dark, and intracytoplasmic vacuoles are absent…
Putative Precursor Lesions of Gestational Trophoblastic Neoplasia
Fig. 5.1 Microscopic features of complete hydatidiform mole (CHM). (a, b) Well-developed CHM with large hydropic villi and central cistern formation. Circumferential trophoblast hyperplasia is also present. (c, d) Early…
Vaginal Intraepithelial Neoplasia
Vagina Cervix aLow-risk HPV aHigh-risk HPV aLow-risk HPV aHigh-risk HPV LSIL 81 18, 51 6, 11 18 42, 43, 54, 62, 67 56, 66 16, 66 16, 39, 52,…
Clinical Management of Selected Precancerous Lesions in the Lower Genital Tract
Fig. 14.1 Overview of clinical management for precancerous cervical lesions. WHO World Health Organization, SIL squamous intraepithelial lesion, GIL glandular intraepithelial lesion, CIN1 cervical intraepithelial neoplasia grade 1, CIN2 cervical…
Putative Precursors of Uterine Sarcomas
Fig. 6.1 Cartoon diagram highlights the anatomic site for tumor origin of uterine sarcoma Table 6.1 FIGO staging for uterine sarcomas (2009) [3] Stage Surgical-pathologic findings Leiomyosarcomas and endometrial stromal…
Precursors of High-Grade Serous Carcinoma
Alterations P53 signature Serous tubal intraepithelial lesion (STIL) Serous tubal intraepithelial carcinoma (STIC) High-grade serous carcinoma P53 Mutated (LOH) Mutated Mutated (LOH) Mutated (LOH) BRCA1/BRCA2 Mutated/LOH Mutated/LOH/hypermethylated Genes (FISH) CCNE1…
Precancerous Lesions of Squamous Cell Carcinoma of the Cervix: Squamous Dysplasia
Fig. 13.1 HSIL/CIN3 and atypical mitotic figure. Nuclear atypia extends through the full epithelial thickness without any cytoplasmic maturation in the superficial epithelial layers. Note the nuclear size and nuclear/cytoplasmic…
Precursors of Low-Grade Serous Adenocarcinoma of the Ovary: Pathology and Molecular Pathways
Fig. 2.1 (a) Ovarian cyst with surface involvement by friable papillary excrescences. They appear to cover most of the ovarian cyst surface. (b) The inner lining of the same ovarian…
