Pharmacokinetics is the study of drug movement through the body, and describes the absorption, distribution, metabolism, and excretion of a substance (1,2). Pharmacokinetics determines how a specific…
INTRODUCTION The electroencephalogram (EEG) is the single most informative laboratory test in evaluating children with seizures. At the most rudimentary level, it helps in differentiating epileptic from…
As a group, the convulsive disorders are among the most frequently occurring neurologic conditions in children. In the United States, approximately 5% of children and adolescents experience…
INTRODUCTION Neuroimaging is a standard part of the evaluation of patients with focal epilepsy and any type of epilepsy in the setting of abnormal cognitive development. In…
INTRODUCTION The purpose of this chapter will be to review selected neuropathologic substrates of intractable epilepsy, including lesions that cause seizures in infants and children, as well…
INTRODUCTION Neuroimaging in epilepsy is undergoing a renaissance. Gone are the days of just “making sure there wasn’t anything big or acute.” Thin slice MRI, fMRI, diffusion…
Childhood epilepsies are often characterized by a wide range of seizure types and accompanying comorbidities such as mental impairment or developmental delay (MI/DD), autism spectrum disorders, and…
INTRODUCTION The particular epileptic conditions outlined in this chapter are very different from each other. However, they share a similar age of onset and the presence of…
INTRODUCTION Functional neuroimaging has contributed to the surgical management of epilepsy in two ways. First, functional imaging methods have facilitated decision making regarding the optimal placement of…
Since phenytoin was introduced for the treatment of epilepsy by Merritt and Putnam in 1938, it has become one of the most widely used and extensively investigated…
