Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress

May 2, 2017 by in GYNECOLOGY Comments Off on Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress

Background Neonatal respiratory distress syndrome in preterm infants is a leading cause of neonatal death. Pulmonary insufficiency-related infant mortality rates have improved with antenatal glucocorticoid treatment and neonatal surfactant replacement….

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Sildenafil treatment in a nonsevere hypertensive murine model lowers blood pressure without reducing fetal growth

May 2, 2017 by in GYNECOLOGY Comments Off on Sildenafil treatment in a nonsevere hypertensive murine model lowers blood pressure without reducing fetal growth

Background Treatment of nonsevere hypertension during pregnancy is controversial. Sildenafil is a phosphodiesterase inhibitor that potentiates nitric oxide by promoting vasodilation. Nitric oxide plays a vital role in mediating the…

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Prenatal exposure to gestational diabetes mellitus as an independent risk factor for long-term neuropsychiatric morbidity of the offspring

May 2, 2017 by in GYNECOLOGY Comments Off on Prenatal exposure to gestational diabetes mellitus as an independent risk factor for long-term neuropsychiatric morbidity of the offspring

Background The reported rates of gestational diabetes mellitus are constantly escalating and little is known about long-term complications in the offspring. Evidence from the field of epigenetics strongly advocates the…

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Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model

May 2, 2017 by in GYNECOLOGY Comments Off on Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model

Introduction Maternal bacterial and viral infections during pregnancy are significant risk factors in several neurobehavioral disorders including cerebral palsy (CP), schizophrenia, and mental retardation. Most recently, epidemiologic studies suggest that…

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High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

May 2, 2017 by in GYNECOLOGY Comments Off on High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

Background Consumption of fructose-rich diets in the United States is on the rise and thought to be associated with obesity and cardiometabolic diseases. Objective We sought to determine the effects…

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Detoxification from opiate drugs during pregnancy

May 2, 2017 by in GYNECOLOGY Comments Off on Detoxification from opiate drugs during pregnancy

Materials and Methods This study was a retrospective analysis of data collected prospectively during ongoing prenatal care of opiate addicted pregnant women managed by the Maternal-Fetal Medicine Department at the University…

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