Liposomes: a nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model

May 6, 2017 by in GYNECOLOGY Comments Off on Liposomes: a nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model

Objective Indomethacin (IND) is a prostaglandin production inhibitor that reduces uterine contractions, but crosses the placenta leading to adverse fetal effects. Liposomes (LIP) are nanoscale systems clinically used to preferentially…

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Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood

May 6, 2017 by in GYNECOLOGY Comments Off on Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood

Objective The purpose of this study was to investigate the association of trimester-specific gestational weight gain with offspring fetal growth, obesity risk, and cardiometabolic health outcomes from birth to 4…

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Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial

May 6, 2017 by in GYNECOLOGY Comments Off on Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial

Materials and Methods Study design and setting This was a single-center, double-blind, placebo-controlled, randomized trial with maternal written consent, conducted in accordance with the standards of the National Maternity Hospital…

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Recognition and response to electronic fetal heart rate patterns: impact on newborn outcomes and primary cesarean delivery rate in women undergoing induction of labor

May 6, 2017 by in GYNECOLOGY Comments Off on Recognition and response to electronic fetal heart rate patterns: impact on newborn outcomes and primary cesarean delivery rate in women undergoing induction of labor

Materials and Methods The Hospital Corporation of America is the nation’s largest provider of inpatient health care, including deliveries. The 110 affiliated hospitals with obstetric and newborn services in 21 states…

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17 alpha-hydroxyprogesterone caproate does not prolong pregnancy or reduce the rate of preterm birth in women at high risk for preterm delivery and a short cervix: a randomized controlled trial

May 6, 2017 by in GYNECOLOGY Comments Off on 17 alpha-hydroxyprogesterone caproate does not prolong pregnancy or reduce the rate of preterm birth in women at high risk for preterm delivery and a short cervix: a randomized controlled trial

Materials and Methods Subjects and screening This open-label, multicenter, randomized controlled trial was performed in 11 university hospitals across France. Women were potentially eligible for inclusion if they presented an…

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Detection of microbial invasion of the amniotic cavity by analysis of cervicovaginal proteins in women with preterm labor and intact membranes

May 6, 2017 by in GYNECOLOGY Comments Off on Detection of microbial invasion of the amniotic cavity by analysis of cervicovaginal proteins in women with preterm labor and intact membranes

Objective Microbial invasion of the amniotic cavity (MIAC) is common in early preterm labor and is associated with maternal and neonatal infectious morbidity. MIAC is usually occult and is reliably…

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