NuMoM2b Sleep-Disordered Breathing study: objectives and methods
Objective The objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk…
Noninvasive prenatal testing: the importance of pretest trisomy risk and posttest predictive values
Objective Noninvasive prenatal testing (NIPT), based on isolation of cell-free fetal DNA from maternal blood, is a highly efficient screening test for trisomies 21, 18, and 13. Guidelines recommend reserving…
Can the practice of nonclosure of visceral and parietal peritoneum during cesarean delivery be justified?
The review by Walfisch et al alongside many other reviews draws out the debate on the peritoneal closure/nonclosure during cesarean delivery. Any discussion on pathophysiologic adhesion-formation most importantly should include that…
The PORTO study and the importance of cerebroplacental ratio in fetal growth restriction
In an earlier publication by the Prospective Observational Trial to Optimize Pediatric Health in Intrauterine Growth Restriction (PORTO) study group, the definition of fetal growth restriction (FGR) in fetuses that…
Safe vaginal uterine morcellation following total laparoscopic hysterectomy
The minimally invasive approach for hysterectomy with proven benefits and lower morbidity has become the gold standard, even in women with large uterine masses. Most women with a malignant condition…
Modified obstetric early warning scoring systems (MOEWS): validating the diagnostic performance for severe sepsis in women with chorioamnionitis
Objective We sought to compare the predictive power of published modified obstetric early warning scoring systems (MOEWS) for the development of severe sepsis in women with chorioamnionitis. Study Design This…
A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b)
Materials and Methods Participants and recruitment Nulliparous women with singleton pregnancies were recruited from hospitals affiliated with 8 clinical centers: Case Western University; Columbia University; Indiana University; University of Pittsburgh;…
Fetal DNA methylation of autism spectrum disorders candidate genes: association with spontaneous preterm birth
Objective Autism spectrum disorder (ASD) is associated with preterm birth (PTB), although the reason underlying this relationship is still unclear. Our objective was to examine DNA methylation patterns of 4…
