Physiologic Considerations Immanuela Ravé Moss Successful transition of the respiratory and pulmonary circulatory system from the fetal to the neonatal state determines postnatal survival. The lungs of the full-term infant…
Developmental Considerations Gross Ian EMBRYOLOGY The lung originates as an outpouching from the endodermal tube that gives rise to the gastrointestinal tract. The epithelial lung bud grows anteriorly into mesenchymal…
Neonatal Abstinence Syndrome Anne M. Johnston Neonatal abstinence syndrome (NAS) refers to a constellation of signs and symptoms caused by drug withdrawal in the newborn. In most cases, drug exposure…
The Floppy Infant and the Late Walker Richard S. K. Young The pediatrician may occasionally discover that an infant has poor head or truncal tone, and laxity in the arms…
Neonatal Seizures Edward J. Novotny Jr. Seizures have long been known to be an important sign of neurologic disease in the newborn and accompany neonatal encephalopathies due to a variety…
Perinatal Cerebral Infarction Laura R. Ment Barbara R. Pober Perinatal cerebral infarction, or stroke, may be defined as the severe disorganization or even complete disruption of the gray and white…
Neonatal Encephalopathies Donna M. Ferriero In the twenty-first century, hypoxic-ischemic encephalopathy (HIE) remains the single most important perinatal cause of neurologic morbidity in both the full-term as well as the…
White Matter Injury in the Premature Infant Jeffrey M. Perlman EPIDEMIOLOGY White matter injury (WMI) represents the most significant problem contributing to both neonatal mortality and long-term neurologic deficits in…
Intraventricular Hemorrhage of the Preterm Infant Laura R. Ment Intraventricular hemorrhage (IVH), or hemorrhage into the germinal matrix tissues with possible rupture into the ventricular system and parenchyma of the…
Neuroembryology Laura R. Ment Barbara R. Pober Congenital malformations of the central nervous system represent a major cause of infantile mortality and morbidity and result in neuroanatomic abnormalities that range…
