Drugs for Hyperbilirubinemia David K. Stevenson Ronald J. Wong Susan R. Hintz Hendrik J. Vreman Introduction Hyperbilirubinemia is a natural and essentially ubiquitous transitional phenomenon among human newborns. Approximately 60%…
The Excretion of Drugs and Chemicals in Human Milk Cheston M. Berlin Jr. Introduction During the 1960s and the early 1970s, the incidence of breastfeeding reached a nadir; in 1972…
Renal Function and Excretion of Drugs in the Newborn John N. van den Anker Karel Allegaert A thorough understanding of the developmental changes in neonatal renal function is needed to…
Perinatal Origins of Adult Defects in Drug Metabolism Bernard H. Shapiro One of the hot topics in medicine today is the so-called fetal origins of adult diseases. This intriguing topic…
Principles of Neonatal Pharmacology Jeffrey L. Blumer Michael D. Reed Introduction The history of drug therapy is replete with examples of adverse reactions to drugs in children. Virtually all the…
Maternal Drug Intake and the Newborn Nada Djokanovic Rada Boskovic Gideon Koren Introduction The use of prescription drugs during pregnancy has become a concern since the thalidomide tragedy. However, medication…
Biotransformation of Medications by Human Placenta Olga Zharikova Tatiana Nanovskaya Mahmoud S. Ahmed Introduction Human placenta is a tissue of fetal origin located at the interface between the maternal and…
Developmental Toxicology Donald R. Mattison Introduction The United States has made progress in maternal and infant health (1,2,3,4); infant mortality has fallen (Fig. 11.1) as a consequence of pediatric nutrition,…
Drug Formulations Milap C. Nahata A continuing decline in the morbidity and mortality in the pediatric population can be attributed, in part, to the availability of effective drugs for preventing…
Therapeutic Drug Monitoring Alexander A. Vinks Philip D. Walson Introduction The simplest way to identify interindividual variability in drug response is to objectively measure the degree of effect and then…
