Obstetrical complications, often referred to as the “great obstetrical syndromes,” are among the most common global causes of mortality and morbidity in young women and their infants. However, treatments for…
Philippe Jeanty, MD, PhD, a pioneer in obstetric and gynecologic ultrasound, has made key contributions to the study of fetal anatomy, biometry, growth, and the diagnosis of congenital anomalies. He…
Obstetrical healthcare providers frequently field questions about the safety of medications recommended or prescribed to their pregnant patients. Most women use as least 1 medication during pregnancy; however, there is…
The data available to inform pregnant and lactating women about drug safety and efficacy are woefully inadequate. This lack of information encompasses every aspect of pharmaceutics, including limited human data…
Achondrogenesis Types IA and IB Low Nasal Bridge, Very Short Limbs, Incomplete Ossification of Lower Spine This early lethal disorder was described in 1925 by Donath and Vogl and termed…
Coffin-Siris Syndrome Hypoplastic to Absent Fifth Finger and Toenails, Coarse Facies Coffin and Siris reported three patients with this disorder in 1970. Coffin-Siris syndrome (CSS) and Nicolaides Baraitser syndrome are…
Multiple Synostosis Syndrome (Symphalangism Syndrome) Symphalangism, Hypoplasia of Alae Nasi In the past this disorder was generally termed symphalangism (synostosis of finger joints), a nonspecific anomaly. The multiple synostosis character…
Fetal Alcohol Spectrum Disorders Prenatal Onset of Growth Deficiency, Microcephaly, Short Palpebral Fissures In 1968, Lemoine of Nantes, France, recognized the multiple effects that alcohol can have on the developing…
The following compilation of normal measurements is set forth as an aid in determining whether or not a given feature is abnormal. Such data may be especially useful when the…
Minor anomalies are herein defined as unusual morphologic features that are of no serious medical or cosmetic consequence to the patient. The value of their recognition is that they may…
