Biotransformation of Medications by Human Placenta Olga Zharikova Tatiana Nanovskaya Mahmoud S. Ahmed Introduction Human placenta is a tissue of fetal origin located at the interface between the maternal and…
Developmental Toxicology Donald R. Mattison Introduction The United States has made progress in maternal and infant health (1,2,3,4); infant mortality has fallen (Fig. 11.1) as a consequence of pediatric nutrition,…
Drug Formulations Milap C. Nahata A continuing decline in the morbidity and mortality in the pediatric population can be attributed, in part, to the availability of effective drugs for preventing…
Therapeutic Drug Monitoring Alexander A. Vinks Philip D. Walson Introduction The simplest way to identify interindividual variability in drug response is to objectively measure the degree of effect and then…
Ethics of Drug Research in Pediatric Populations Bruce A. Russell Sanford N. Cohen Virginia Delaney-Black Why Research on Children is Needed The majority of pharmacologic agents and pharmaceutical preparations currently…
Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations Steven Hirschfeld Brief History of Research Involving Children Children have been utilized to test new therapies for thousands of…
Adherence with Pediatric Medication Regimens Hakan Ergün Daniel A.C. Frattarelli Doreen Matsui Introduction In pharmacotherapy, the terms “compliance” and “adherence” are often used interchangeably, although the latter term is preferred…
Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics J. Steven Leeder Introduction It is readily accepted that genetic factors play an important role in influencing a child’s potential physical characteristics such as height, weight,…
Drug Metabolism and Disposition in Infants and Children Anders Rane The new regulatory framework for development of drugs for children has promoted the interest in pediatric pharmacology and left behind…
Clinical Pharmacokinetics in Infants and Children Edmund V. Capparelli Introduction Considerable growth has occurred in the number of new chemical and biologic treatments during the last 25 years. Appropriate use…
