Fig. 23.1 Uterine papillary serous carcinoma. Note the fibrovascular core lined by stratified, pleomorphic cells, forming secondary papillae and cellular buds Clear-cell cancers are more varied, often characterized by tubulocystic,…
Route of recurrence Risk factors Hematogenous All stages of disease Myometrial invasion >50 % Stage I disease, negative LNs Myometrial invasion ≥66 % Lymphatic Pelvic/paraaortic LNs CSI, LN metastases Peritoneal…
Fig. 38.1 CT scan showing enlarged uterus with cystic spaces and thinned out myometrium A differential diagnosis of uterine sarcoma/endometrial malignancy was made on imaging. CA125 and LDH were within…
Disease related Neuropathy secondary to uncontrolled diabetes mellitus Tumor infiltration and nerve impingement Gynecologic malignancy-specific pain syndromes Lumbosacral plexopathy Pelvic pain Malignant psoas syndrome Treatment related Radiation-induced pain (e.g., proctitis,…
Study Stage Number Clinical outcome Kapp et al. [8] I 951 5-year DSS: 76 % II 43 5-year DSS: 60 % III 99 5-year DSS: 45 % IV 303 5-year…
SERM Breast Uterus Tamoxifen − ++ Raloxifene − − Toremifene − +/− Idoxifene − +/− Droloxifene − +/− GW 5638 − +/− Arzoxifene − − EM-652 − +/− Many of…
Stage 5 years survival (%) 1A 88 1B 75 11 69 111A 58 111B 50 111C 47 1v A 17 1v B 15 Types of the Tumor There are two…
NCEP-ATPIII [75] Modified WHO [9] EGIR [76] AACE [77] IDF [1] Simplified definition of metabolic syndrome [78] Mandatory … Insulin resistancea >75th percentile glucose ≥110 mg/dL; 2 h glucose…
Characteristic Type I Type II Chronic estrogenic stimulation Present (hormone dependent) Absent (not hormone dependent) Growth Slow growing Rapid Precursor lesion Atypical hyperplasia Endometrial intraepithelial carcinoma Age at initial diagnosis…
Fig. 15.1 Lymph node evaluation road map. SLN, sentinel lymph node; LND, lymphadenectomy Sentinel Lymph Nodes and Endometrial Cancer The first reported use of SLN mapping in endometrial cancer was…
