Continent Countries included/submitted data PBCR included/submitted data Geographic coverage by continent (%) Population coverage in millions (%) Africa 5/14 5/16 31 8.8 (1 %) Asia 15/18 44/77 57 152.3 (4…
Medication Indication Route Initial dosage Maximum Frequency Dexamethasone Raised intracranial pressure, nausea and vomiting PO/NG, SC, IV 1–2 mg/kg (initial) 4–10 mg/dose Q6–12 h 0.25–0.5 mg/kg Ondansetron Nausea and vomiting…
Fig. 24.1 Predictors of neuropsychological outcome in PBTS Neuropsychological Outcomes There is considerable heterogeneity in individual neuropsychological outcomes for PBTS given the variety of tumor types and/or treatments and associated…
Characteristic Definition 1. Subjective QoL is an individual perception and the only reliable source for evaluation—it is the person itself 2. Phenomenological QoL is perceived. It is like a photograph,…
Reference Classification system Epstein [2] Intrinsic Diffuse Focal Cervicomedullary Exophytic Anterolateral Posterolateral Disseminated Positive CSF cytology Positive myelography Choux et al. [3] Type I Diffuse Type II Intrinsic, focal Type…
High level of emetic risk (>90 % frequency of emesis in absence of prophylaxis) Altretamine Dactinomycin Carboplatin Mechlorethamine Carmustine >250 mg/m2 Methotrexate ≥12 g/m2 Cisplatin Procarbazine (oral) Cyclophosphamide ≥1 g/m2…
© Springer Science+Business Media New York 2015Katrin Scheinemann and Eric Bouffet (eds.)Pediatric Neuro-oncology10.1007/978-1-4939-1541-5_21 21. High-Dose Chemotherapy/Stem Cell Transplantation (HDSCT) Victor Anthony Lewis1 and Shahrad Rod Rassekh2 (1) Department of Pediatrics, Alberta Children’s Hospital, Calgary, AB, Canada (2) Division of…
Study type Drug BSG Ependymoma Medulloblastoma/sPNET HGG LGG Other Total Outcome References Phase I Gefitinib 3 (2 SD) 1 4 2 SD [30] Phase I Lonafarnib 7 9 8 18 …
Drug Mechanism of action Common toxicities Less common toxicities Dose ranges Penetration of blood–brain barrier Intravenous Vincristine Vinca alkaloid Constipation, diarrhea, peripheral neuropathy SIADH, paralytic ileus, seizures, severe jaw pain…
Fig. 15.1 Sagittal T1 + gadolinium and coronal T1 + gadolinium sequences of a left large parietal ATRT Pathology As described in Chap. 6, the consistent histologic feature of ATRT…
