Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML), a rare myeloid malignancy that occurs in young children, is considered a clonal disease originating in pluripotent stem cells of the hematopoietic system. The pathogenesis of…
Pediatric Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a molecularly heterogeneous disease and age-associated molecular alterations result in younger children harboring a distinct signature from older children and adolescents. Pediatric AML has a…
Treatment of Pediatric Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the most common pediatric oncologic diagnosis, and advances in its treatment have led to progressive improvements in survival. The 4 main components of therapy are…
Biology of Childhood Acute Lymphoblastic Leukemia
Giant strides have been made in the management of childhood acute lymphoblastic leukemia (ALL) over previous decades. Extensive collaborative efforts internationally have played a vital role in the remarkable progress…
Supportive Care in Pediatric Oncology
Advancements in the care of children with cancer have, in part, been achieved through improvements in supportive care. Situations that require prompt care can occur at the time of presentation…
Genetic and Nongenetic Risk Factors for Childhood Cancer
The causes of childhood cancer have been systematically studied for decades, but apart from high-dose radiation and prior chemotherapy there are few strong external risk factors. However, inherent risk factors…
Evolution of Modern Treatment of Childhood Acute Leukemia and Cancer
This article summarizes the adventures and explorations in the 1970s and 1980s in the treatment of children with leukemia and cancer that paved the way for the current success in…
Acknowledgments
When Dr Bonita Stanton, former chair of the department of Pediatrics and current vice dean for Research at Wayne State University asked me to be the guest editor for this…
