Hematopoietic Stem Cell Therapy
Key Points • Hematopoietic stem cell transplantation (HSCT) can correct many primary immune deficiencies (PIDs) by providing a normal source that produces functional leukocytes to replace the defective cells. •…
Laboratory Diagnosis of Human Allergic Disease
Key Points • Allergen-specific IgE antibody is a marker of allergic sensitization and a risk factor for allergic disease but, alone, it does not make the definitive diagnosis of allergic…
Biologic Therapies
Key Points • Biologics are mostly large molecules, usually proteins, that serve as therapeutics and are derived from living organisms. • Biologics produced in vitro by recombinant technology are monoclonal…
Immunoglobulin Therapy
Key Points • Replacement immune globulin, administered by intravenous or subcutaneous route, is indicated as replacement therapy in patients with antibody immunodeficiency disorders. • Dosing intravenous immune globulin (IVIG) to…
Autoinflammatory Disorders
Key Points • In the majority of the autoinflammatory diseases innate immune system dysregulation is the cause of the inflammation. • Most of these conditions have a monogenic cause. •…
Congenital Immune Dysregulation Disorders
Key Points • Monogenic defects have been identified that interfere with self tolerance. • Human defects of self tolerance can affect both central and peripheral tolerance. • Linking specific genetic…
Rheumatic Diseases of Childhood: Therapeutic Principles
Key Points • Rheumatologic disorders are perpetuated by ongoing immune activation resulting from failure to clear triggering antigens combined with aberrant control mechanisms. • The resulting chronic inflammation leads to…
Defects of Innate Immunity
Key Points • White blood cells (lymphoid or myeloid) can suffer from quantitative or functional congenital disorders. • The type of cells or mechanisms that are mainly affected will define…
Inflammatory and Effector Cells/Cell Migration
Key Points • A hallmark of allergic inflammation is the accumulation of a large number of leukocytes, including eosinophils, neutrophils, lymphocytes, basophils and macrophages, in the inflammatory tissues. • Leukocyte…
Regulation and Biology of Immunoglobulin E
Key Points • IgE-producing B cells arise from IgM + or IgG + B cells via the process of class switch recombination (CSR). B cells undergoing CSR undergo somatic gene…
