The Kidney

Jun 19, 2016 by in PEDIATRICS Comments Off on The Kidney

Podocin deficiency or podocin-induced focal segmental glomerulosclerosis (FSGS) accounts for 10% to 30% of cases of pediatric steroid-resistant nephrotic syndrome. The age of onset ranges from younger than 1 year…

read more

Skin

Jun 19, 2016 by in PEDIATRICS Comments Off on Skin

Darier disease is an autosomal dominant disorder caused by mutations in the ATP2A2 gene6 that typically presents in children aged 5 to 15 years as keratotic papules in “seborrheic” distribution…

read more

Hematopoietic System

Jun 19, 2016 by in PEDIATRICS Comments Off on Hematopoietic System

BONE MARROW Considerations on the Normal Marrow What is “normal” for a pediatric patient? The bone marrow is very dynamic in childhood, as reflected by the changes in hematologic values…

read more

The Liver

Jun 19, 2016 by in PEDIATRICS Comments Off on The Liver

Neonatal Cholestasis Cholestasis is biochemically characterized by conjugated or mixed hyperbilirubinemia, with elevated alkaline phosphatase and GGT, although some cases of PFIC and bile acid synthesis defects may have normal…

read more

Gastrointestinal System

Jun 19, 2016 by in PEDIATRICS Comments Off on Gastrointestinal System

Herpes simplex virus (HSV) esophagitis occurs primarily in immunocompromised patients, who may have life-threatening disease at the time of diagnosis.2 In immunocompetent patients, the infection is self-limited and resolves spontaneously…

read more

Central Nervous System and Skeletal Muscle

Jun 19, 2016 by in PEDIATRICS Comments Off on Central Nervous System and Skeletal Muscle

Pediatric CNS tumors are classified according to the World Health Organization (WHO) classification.1,2 The assigned WHO grade describes the biology of the lesion, but a low grade does not always…

read more

The Lung

Jun 19, 2016 by in PEDIATRICS Comments Off on The Lung

Yeasts Differentiating features of yeasts in tissue include size (including size variability), shape of budding, formation of pseudohyphae, and pattern of inflammatory response (eTable 9.2). If only a few organisms…

read more

Soft Tissue

Jun 19, 2016 by in PEDIATRICS Comments Off on Soft Tissue

BIOPSY DIAGNOSIS OF SOFT TISSUE LESIONS Biopsies of soft tissue tumors may be performed in several different ways. These include fine needle aspiration, large-needle core biopsy, open incisional biopsy, and…

read more

Bone

Jun 19, 2016 by in PEDIATRICS Comments Off on Bone

Metabolic Disorders of Bone Bone biopsies may be used in the diagnosis of metabolic bone diseases in the pediatric population, such as rickets and renal osteodystrophy. Bone biopsy may also…

read more
Get Clinical Tree app for offline access