Objective In 2017, the American College of Cardiology and the American Heart Association classified “stage 1 hypertension” as blood pressure (BP) of 130 to 139/80 to 89 mm Hg in…
Ovarian cancer staging by imaging, is still a challenging process. Experienced gynecologic sonographers are required for the detection and staging of ovarian cancer. We report the case of a symptomatic…
Objective Exome sequencing (ES), or sequencing of the protein coding regions of the genome, has revolutionized medicine and offers significant promise for prenatal diagnosis. Current studies emphasize the technical feasibility…
Background Laboratories offering cell-free DNA often reserve the right to share prenatal genetic data for research or even commercial purposes, and obtain this permission on the patient consent form. Although…
Background Umbilical cord arterial and venous blood gas values reflect the acid-base balance status of a newborn at birth. Derangement in these values has been linked to poor neonatal outcomes…
Background Preterm birth is the largest single cause of infant death in the United States. A cervical length of <2.5 cm, measured in the mid-trimester, has been shown to identify…
Background Preeclampsia presents a highly prevalent burden on pregnant women with an estimated incidence of 2% to 5%. Preeclampsia increases the maternal risk of death 20-fold and is one of…
Background Intrauterine growth restriction is associated with an increased risk of cardiovascular changes neonatally. However, the underlying pathways are poorly understood, and it is not clear whether the dysfunction is…
Background Historically, prenatal screening has focused primarily on the detection of fetal aneuploidies. Cell-free DNA now enables noninvasive screening for subchromosomal copy number variants, including 22q11.2 deletion syndrome (or DiGeorge…
Background Spontaneous preterm birth remains the main driver of childhood morbidity and mortality. Because of an incomplete understanding of the molecular pathways that result in spontaneous preterm birth, accurate predictive…
