Serial cervical length determination in twin pregnancies reveals 4 distinct patterns with prognostic significance for preterm birth

May 2, 2017 by in GYNECOLOGY Comments Off on Serial cervical length determination in twin pregnancies reveals 4 distinct patterns with prognostic significance for preterm birth

Background Women with a twin gestation are at increased risk for preterm birth (PTB), and sonographic cervical length (CL) is a powerful predictor for spontaneous PTB. Obstetricians frequently monitor CL…

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The association of early unexplained elevated alanine aminotransferase with large-for-gestational-age birthweight

May 2, 2017 by in GYNECOLOGY Comments Off on The association of early unexplained elevated alanine aminotransferase with large-for-gestational-age birthweight

Background Nonalcoholic fatty liver disease causes hepatic insulin resistance and is associated with metabolic syndrome. Elevated levels of alanine aminotransferase are associated with nonalcoholic fatty liver disease. The effect of…

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Omission of fetal sampling in treatment of subsequent pregnancies in fetal-neonatal alloimmune thrombocytopenia

May 2, 2017 by in GYNECOLOGY Comments Off on Omission of fetal sampling in treatment of subsequent pregnancies in fetal-neonatal alloimmune thrombocytopenia

Background Fetal-neonatal alloimmune thrombocytopenia affects approximately 1 of 1000 live births, most of which are not severely thrombocytopenic. Despite effective treatment with intravenous gammaglobulin and/or prednisone, antenatal management of a…

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Urinary congophilia in women with hypertensive disorders of pregnancy and preexisting proteinuria or hypertension

May 2, 2017 by in GYNECOLOGY Comments Off on Urinary congophilia in women with hypertensive disorders of pregnancy and preexisting proteinuria or hypertension

Background Congophilia indicates the presence of amyloid protein, which is an aggregate of misfolded proteins, that is implicated in the pathophysiologic condition of preeclampsia. Recently, urinary congophilia has been proposed…

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Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network

May 2, 2017 by in GYNECOLOGY Comments Off on Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network

Background An evaluation for heritable thrombophilias is recommended in the evaluation of stillbirth. However, the association between thrombophilias and stillbirth remains uncertain. Objective We sought to assess the association between…

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Maternal and pregnancy characteristics affect plasma fibrin monomer complexes and D-dimer reference ranges for venous thromboembolism in pregnancy

May 2, 2017 by in GYNECOLOGY Comments Off on Maternal and pregnancy characteristics affect plasma fibrin monomer complexes and D-dimer reference ranges for venous thromboembolism in pregnancy

Background D-dimers have a high negative predictive value for excluding venous thromboembolism outside of pregnancy but the use in pregnancy remains controversial. A higher cut-off value has been proposed in…

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The effect of major depression on quality of life after surgery for stress urinary incontinence: a secondary analysis of the Trial of Midurethral Slings

May 2, 2017 by in GYNECOLOGY Comments Off on The effect of major depression on quality of life after surgery for stress urinary incontinence: a secondary analysis of the Trial of Midurethral Slings

Background Depression has been associated with symptom amplification, functional impairment, and lower incontinence-specific quality of life in women with urinary incontinence. Although depression has been shown to impact both subjective…

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Safety of ovarian preservation in women with stage I and II cervical adenocarcinoma: a retrospective study and meta-analysis

May 2, 2017 by in GYNECOLOGY Comments Off on Safety of ovarian preservation in women with stage I and II cervical adenocarcinoma: a retrospective study and meta-analysis

Introduction The incidence of cervical cancer has declined markedly over the past several decades, due to the wide implementation of cytologic screening and increased detection of premalignant disease. However, the…

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In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study

May 2, 2017 by in GYNECOLOGY Comments Off on In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study

Introduction Congenital cytomegalovirus (CMV) infection affects 0.7% of live births and is the leading cause of congenital neurological disease of infectious origin. Among all neonates positive for infection on screening,…

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The impact of surgical complications on health-related quality of life in women undergoing gynecologic and gynecologic oncology procedures: a prospective longitudinal cohort study

May 2, 2017 by in GYNECOLOGY Comments Off on The impact of surgical complications on health-related quality of life in women undergoing gynecologic and gynecologic oncology procedures: a prospective longitudinal cohort study

Introduction Patient-centered outcomes are of increasing importance in medical research. The Affordable Care Act provided $150 million in annual funding for the Patient-Centered Outcome Research Institute, an organization expressly committed to…

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