Prenatal aneuploidy screening using cell-free DNA

May 5, 2017 by in GYNECOLOGY Comments Off on Prenatal aneuploidy screening using cell-free DNA

We sincerely thank the Society for Maternal-Fetal Medicine Publication Committee for its recent article that addressed noninvasive prenatal testing (NIPT). The document provides invaluable information and guidance for practitioners. A…

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May 5, 2017 by in GYNECOLOGY Comments Off on Reply

The thoughtful comments of Drs Hallman, Personen, and Teramo regarding our recently published metaanalysis are appreciated. We are aware of the ongoing interest of these researchers on the adverse effects…

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Indomethacin as a tocolytic harmful to preterm infant

May 5, 2017 by in GYNECOLOGY Comments Off on Indomethacin as a tocolytic harmful to preterm infant

Amy Hammers et al recently published a critical metaanalysis of indomethacin as a tocolytic that demonstrated evidence of harmful effects to preterm infants. The investigators have used rigorous methods for metaanalysis…

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May 5, 2017 by in GYNECOLOGY Comments Off on Reply

We thank Henderson et al for the interest shown in our study and would like to offer our comments in reply. In our study, we had 1 case of intrauterine fetal…

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Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface

May 5, 2017 by in GYNECOLOGY Comments Off on Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface

Objective Progestogen (vaginal progesterone or 17-alpha-hydroxyprogesterone caproate [17OHP-C]) administration to patients at risk for preterm delivery is widely used for the prevention of preterm birth (PTB). The mechanisms by which these…

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Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies

May 5, 2017 by in GYNECOLOGY Comments Off on Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies

We welcomed the evidence-based report by Raz et al describing a relationship between intrahepatic cholestasis of pregnancy (ICP) and preeclampsia. They tested a plausible hypothesis that elevated serum bile acids (the…

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May 5, 2017 by in GYNECOLOGY Comments Off on Reply

We thank Dr Serati et al for their letter to the editor about our paper. They posit that our observed higher risk of gestational diabetes mellitus and large-for-gestational birthweight might be…

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