Objectives To estimate the association between antimicrobial peptide, cytokine, and chemokine concentrations in cervicovaginal secretions and in vitro HIV infectivity among pregnant and non-pregnant women. Methods Longitudinal prospective cohort study…
Objectives To determine whether specific features of placental pathology correlate with fetal injury, the fetal inflammatory response syndrome (FIRS) and/or fetal and amniotic fluid cytokine levels during experimental infection-induced preterm…
Objectives Uterine contractility may be initiated through inflammation-related pathways. Progesterone, an endogenous hormone, is thought to mitigate preterm labor partly through anti-inflammatory effects. Our lab has previously identified mono-hydroxylated metabolites…
Objectives Sexually transmitted infections (STIs) lead to female reproductive morbidity, are frequently asymptomatic, and rates continue to rise. Adolescents are known to be at high risk for STIs and have…
Objectives Trichomonas vaginalis is a risk factor for the acquisition and transmission of HIV. The highly sensitive T. vaginalis nucleic acid amplification test (NAAT) recently became available for routine diagnostic…
Objectives Nucleic acid amplification testing (NAAT) is commercially available for the diagnosis of vaginitis, but only validated in the setting of a STD clinic. The aim of this study was…
Objectives SYM-1219, a granule formulation of secnidazole, a 5-nitroimidazole with a longer half-life (∼17 hr) than metronidazole (∼8 hr), is being developed to treat bacterial vaginosis (BV). Secnidazole has been…
Materials and Methods Animals and treatments Sprague-Dawley pregnant rats (total of 24, 6 in each group) (Harlan Sprague Dawley, Inc, Chicago, IL) were obtained at gestational day 11 (term = 21…
Click Supplementary Content under the article title in the online Table of Contents Case notes A 34-year-old G2P0010 presents for nuchal translucency at 12 weeks’ gestation. Ultrasound revealed a dolichocephalic fetus…
Objectives Data are limited on the potential impact of the injectable progestin contraceptives (IPC) norethisterone enanthate on risk of vaginal infections. We assessed whether users of two common IPC (depot…
