Noninvasive prenatal testing for 22q11.2 deletion syndrome: deeper sequencing increases the positive predictive value

May 6, 2017 by in GYNECOLOGY Comments Off on Noninvasive prenatal testing for 22q11.2 deletion syndrome: deeper sequencing increases the positive predictive value

Our recent study entitled, “Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes” by Wapner et al, demonstrated that single-nucleotide polymorphism-based noninvasive prenatal testing had high sensitivity and…

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May 6, 2017 by in GYNECOLOGY Comments Off on Reply

We thank Dr Singh for his interest in our study on aneuploidy detection using noninvasive prenatal testing. Details of the 31,030 tests received for analysis, including 17,885 available for clinical follow-up,…

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Clinical experience and follow-up with large-scale single-nucleotide polymorphism–based noninvasive prenatal aneuploidy testing

May 6, 2017 by in GYNECOLOGY Comments Off on Clinical experience and follow-up with large-scale single-nucleotide polymorphism–based noninvasive prenatal aneuploidy testing

I presume this article was published to inform obstetricians about the performance of the Panorama noninvasive prenatal screening test (NIPT) sold by Natera. As a practicing obstetrician, I have been…

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May 6, 2017 by in GYNECOLOGY Comments Off on Reply

As Dr Wertheim has suggested, it would be ideal if we could collect “all relevant information.” However, at this point, we collect as much information as is practically feasible. The…

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May 6, 2017 by in GYNECOLOGY Comments Off on Reply

We thank Dr Moaddab and colleagues for their response to our recent article regarding obstetrics and gynecology residency program directors’ assessments of resident ethics education. We agree that while role…

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The effect of latency of time, centrifugation conditions, supernate filtration, and addition of protease inhibitors on amniotic fluid interleukin-6 concentrations

May 6, 2017 by in GYNECOLOGY Comments Off on The effect of latency of time, centrifugation conditions, supernate filtration, and addition of protease inhibitors on amniotic fluid interleukin-6 concentrations

Objective Amniotic fluid specimens are commonly frozen and stored for research purposes. A previous study examined the stability of certain cytokines in stored amniotic fluid samples for prolonged periods of…

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