Obgyn Key

Objective Intrauterine growth restricted (IUGR) fetuses experience cardiovascular remodeling that persists into infancy and has been related to cardiovascular outcomes in adulthood. Hypertension in infancy has been demonstrated to be…

Materials and Methods This is a secondary analysis of data from the Preterm Prediction Study, a multicenter prospective observational cohort study conducted by the National Institute of Child Health and…

Objective The purpose of this study was to assess whether abnormal cardiac function in human fetuses with intrauterine growth restriction (IUGR) is associated with ultrastructural differences in the cardiomyocyte sarcomere….

Objective Soluble fms-like tyrosine kinase (sFlt-1) is an important mediator in the pathogenesis of preeclampsia. We sought to determine whether platelet-monocyte aggregates (PMAs) produced sFlt-1 and whether PMAs contributed to…

Objective Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in…

Objective Preeclampsia alters fetal programming and results in long-term metabolic consequences in the offspring. Pravastatin has been shown to prevent preeclampsia in animal models. Our aim was to characterize the…

Materials and Methods We conducted a 4 year retrospective cohort study of all consecutive term (gestation of ≥37 weeks) deliveries at Washington University School of Medicine (St. Louis, MO) from…

Objective Women with a history of preeclampsia (PE) have an increased prevalence of cardiometabolic, cardiovascular, and prothrombotic risk factors. Remotely, these women are at increased risk of developing cardiovascular and…

Materials and Methods The Leiden University Medical Center serves as the national referral center for laser treatment in TTTS pregnancies in The Netherlands since 2000. Surviving children of all TTTS…