Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression

May 25, 2017 by in GYNECOLOGY Comments Off on Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression

Objective Antibody-mediated disruption of the annexin A5 anticoagulant shield has been posited to be a thrombogenic mechanism in the antiphospholipid syndrome. We recently showed that the antimalarial drug, hydroxychloroquine, dissociates…

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Antenatal suspicion of ischemic placental disease and coexistence of maternal and fetal placental disease: analysis of over 500 cases

May 25, 2017 by in GYNECOLOGY Comments Off on Antenatal suspicion of ischemic placental disease and coexistence of maternal and fetal placental disease: analysis of over 500 cases

Objective To investigate the antenatal suspicion of placental disease and the coexistence of maternal and fetal placental ischemic disease. Study Design A prospective cohort study on normally formed singleton infants…

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Sonography-based Automated Volume Count to estimate fetal urine production in twin-to-twin transfusion syndrome: comparison with Virtual Organ Computer-aided AnaLysis

May 25, 2017 by in GYNECOLOGY Comments Off on Sonography-based Automated Volume Count to estimate fetal urine production in twin-to-twin transfusion syndrome: comparison with Virtual Organ Computer-aided AnaLysis

Objective Sonography-based Automated Volume Count (SonoAVC) is an automated, operator-independent, 3-dimensional ultrasound technique. The study goal was to assess agreement between SonoAVC and Virtual Organ Computer-aided AnaLysis (VOCAL) for bladder…

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Quantitative analysis of renal vascularization in fetuses with urinary tract obstruction by three-dimensional power-Doppler

May 25, 2017 by in GYNECOLOGY Comments Off on Quantitative analysis of renal vascularization in fetuses with urinary tract obstruction by three-dimensional power-Doppler

Objective To evaluate the applicability of 3-dimensional evaluation of renal vascularization for predicting postnatal renal function in fetuses with suspected urinary obstruction. Study Design Fetuses were evaluated by 3-dimensional power-Doppler…

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Cervical carcinomas overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody

May 25, 2017 by in GYNECOLOGY Comments Off on Cervical carcinomas overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody

Objective We evaluated the expression of human trophoblast cell-surface marker (Trop-2) and the potential of hRS7, a humanized monoclonal anti-Trop-2 antibody, against treatment-refractory cervical cancer. Study Design Trop-2 expression was…

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