Of parachutes and patient care: a call to action

May 28, 2017 by in GYNECOLOGY Comments Off on Of parachutes and patient care: a call to action

Obstetric caregivers are plagued with lawsuits alleging negligence for suboptimal outcomes. Some of those claims are unjustified, but many have merit. We are obligated to create systems designed to minimize…

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Bloody mess

May 28, 2017 by in GYNECOLOGY Comments Off on Bloody mess

Women with positive antiphospholipid antibodies may present with severe preeclampsia, fetal growth restriction (FGR), fetal demise, and recurrent miscarriage. In addition, these women are at increased risk of arterial and…

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SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy

May 28, 2017 by in GYNECOLOGY Comments Off on SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy

Objective Oxidative stress plays a causative role in diabetic embryopathy. We tested whether mitigating oxidative stress, using superoxide dismutase 1 (SOD1) transgenic (Tg) mice, would block hyperglycemia-induced specific protein kinase…

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Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats

May 28, 2017 by in GYNECOLOGY Comments Off on Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats

Objective The mechanism of infection-related deaths of pregnant rats and intrauterine growth restriction are not understood. We assessed whether nitric oxide (NO) has differential effects on infection with Escherichia coli…

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The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder

May 28, 2017 by in GYNECOLOGY Comments Off on The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder

Objective The purpose of this study was to verify the association between the Trp 64 Arg polymorphism and idiopathic overactive bladder (OAB) syndrome. Study Design A case-control study was conducted…

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Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model

May 28, 2017 by in GYNECOLOGY Comments Off on Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model

Objective The objective of the study was to compare the influence of collagen-coated vs uncoated polypropylene meshes on the expression of genes critical for wound healing. Study Design In 54…

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Fetal cardiac ventricular volume, cardiac output, and ejection fraction determined with 4-dimensional ultrasound using spatiotemporal image correlation and virtual organ computer-aided analysis

May 28, 2017 by in GYNECOLOGY Comments Off on Fetal cardiac ventricular volume, cardiac output, and ejection fraction determined with 4-dimensional ultrasound using spatiotemporal image correlation and virtual organ computer-aided analysis

Objective The objective of this study was to quantify fetal cardiovascular parameters using spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL). Study Design A cross-sectional study was performed…

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Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

May 28, 2017 by in GYNECOLOGY Comments Off on Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

Objective We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design We conducted nested case-control analysis of…

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