SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy

Jun 5, 2017 by in GYNECOLOGY Comments Off on SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy

Objective Oxidative stress plays a causative role in diabetic embryopathy. We tested whether mitigating oxidative stress, using superoxide dismutase 1 (SOD1) transgenic (Tg) mice, would block hyperglycemia-induced specific protein kinase…

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Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats

Jun 5, 2017 by in GYNECOLOGY Comments Off on Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats

Objective The mechanism of infection-related deaths of pregnant rats and intrauterine growth restriction are not understood. We assessed whether nitric oxide (NO) has differential effects on infection with Escherichia coli…

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A novel optical method to assess cervical changes during pregnancy and use to evaluate the effects of progestins on term and preterm labor

Jun 5, 2017 by in GYNECOLOGY Comments Off on A novel optical method to assess cervical changes during pregnancy and use to evaluate the effects of progestins on term and preterm labor

Objective The purpose of this study was to determine whether optical methods can estimate cervix function during pregnancy and whether progestins modify this process. Study Design Photos of the external…

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The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder

Jun 5, 2017 by in GYNECOLOGY Comments Off on The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder

Objective The purpose of this study was to verify the association between the Trp 64 Arg polymorphism and idiopathic overactive bladder (OAB) syndrome. Study Design A case-control study was conducted…

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Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model

Jun 5, 2017 by in GYNECOLOGY Comments Off on Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model

Objective The objective of the study was to compare the influence of collagen-coated vs uncoated polypropylene meshes on the expression of genes critical for wound healing. Study Design In 54…

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Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

Jun 5, 2017 by in GYNECOLOGY Comments Off on Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

Objective We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design We conducted nested case-control analysis of…

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