Gastrointestinal Drugs Catherine O’Brien Jennifer Lowry Kristine Palmer Henry C. Farrar Gregory L. Kearns Laura P. James Introduction Gastrointestinal disorders are common in children and a wide variety of drugs…

Antihypertensive Agents Thomas G. Wells Mohammad Ilyas Russell W. Chesney Deborah P. Jones Until 1997, few antihypertensive agents were studied systematically in children, and very few were labeled for use…

Nonsteroidal Anti-Inflammatory Drugs Sylvain Chemtob Véronique G. Dorval Inflammation is among the most important tissue responses to injury; it is observed in all acquired disorders as well as genetic conditions…

Local Anesthetic Solutions for Regional Anesthesia in Infants, Children, and Adolescents Santhanam Suresh Charles J. Coté The use of local anesthetics has increased in the pediatric population because of the…

Analgesic Agents Sinno H.P. Simons Brian J. Anderson Dick Tibboel Introduction It was generally believed that neonates were unable to experience pain (1). The importance of antinociceptive therapy in children,…

Immunosuppressive and Immunomodulatory Drugs Amrish Jain Rudolph P. Valentini Tej K. Mattoo Scott A. Gruber Introduction Organ transplantation has been performed successfully in infants, children, and adolescents for over four…

Clinical Pharmacology of Antineoplastic Drugs Stacey L. Berg Lisa R. Bomgaars David G. Poplack Challenges inherent in administering antineoplastic therapy safely to children are numerous. Among the most critical issues…

Diuretics Jean-Pierre Guignard Introduction Diuretics promote the excretion of water and electrolytes. They are primarily used in states of inappropriate salt and water retention. Such states can be secondary to…

Antipyretics John T. Wilson Victoria Tutag Lehr Erika Crane Margaret Ann Springer Introduction Fever has been recognized since antiquity and variously attributed to a myriad of causes from excessive yellow…