Epidemiology of Adverse Drug Effects
Epidemiology of Adverse Drug Effects Louis Vernacchio Allen A. Mitchell Introduction The practice of rational drug therapy requires weighing the benefits expected from the use of a given drug against…
PEDIATRICS
Childhood Vaccines
Childhood Vaccines Evridiki V. Fera Paola J. Maurtua-Neumann David W. Scheifele Pearay L. Ogra Introduction Effective control or total elimination of many childhood infections by vaccinations is one of the…
Nutrient Supplements
Nutrient Supplements Mary Frances Picciano Michelle K. McGuire Paul M. Coates Introduction During infancy and childhood, patterns of healthy growth and development are generally predictable and orderly. Although these growth…
Hematologic Agents
Hematologic Agents Annie Nguyen-Vermillion Sandra E. Juul Introduction The bone marrow of a healthy growing fetus produces billions of cells each day. This challenge is greater in developing individuals than…
Growth Hormone
Growth Hormone Celia Rodd Harvey J. Guyda Introduction The therapeutic use of growth hormone (GH), derived from human cadaveric pituitaries, was introduced in the late 1950s and early 1960s (1)….
Thyroid Hormones
Thyroid Hormones Delbert A. Fisher Thyroid hormones are critically important to normal growth and development during infancy, childhood, and adolescence. Thyroid hormone deficiency during fetal life and infancy leads to…
Insulin and Diabetes Mellitus
Insulin and Diabetes Mellitus Tania S. Burgert Eda Cengiz William Tamborlane Prior to the advent of insulin therapy, the life expectancy of children with type-1 diabetes mellitus (T1DM) was approximately…
Glucocorticoids
Glucocorticoids Evangelia Charmandari Tomoshige Kino George P. Chrousos Introduction Glucocorticoids regulate a broad spectrum of physiologic functions essential for life and play an important role in the maintenance of basal…
Gastrointestinal Drugs
Gastrointestinal Drugs Catherine O’Brien Jennifer Lowry Kristine Palmer Henry C. Farrar Gregory L. Kearns Laura P. James Introduction Gastrointestinal disorders are common in children and a wide variety of drugs…
Antihypertensive Agents
Antihypertensive Agents Thomas G. Wells Mohammad Ilyas Russell W. Chesney Deborah P. Jones Until 1997, few antihypertensive agents were studied systematically in children, and very few were labeled for use…
