Global Infections and Child Health
James P. Nataro, MD, PhD, MBA, Editor At the Millennium Summit in 2000, world leaders articulated an ambitious agenda to reduce extreme poverty, improve child and maternal health, reduce gender…
PEDIATRICS
Global Infections and Child Health
Bonita F. Stanton, MD, Consulting Editor Despite much progress in their control, infectious diseases remain a global concern. The number of under-five deaths worldwide has declined from 12.7 million in…
Global Infections and Child Health
PEDIATRIC CLINICS OF NORTH AMERICA www.pediatric.theclinics.com Consulting Editor BONITA F. STANTON August 2017 • Volume 64 • Number 4
End-of-Life and Bereavement Care in Pediatric Intensive Care Units
Most childhood deaths in the United States occur in hospitals. Pediatric intensive care clinicians must anticipate and effectively treat dying children’s pain and suffering and support the psychosocial and spiritual…
Delirium in Pediatric Critical Care
Delirium occurs frequently in the critically ill child. It is a syndrome characterized by an acute onset and fluctuating course, with behaviors that reflect a disturbance in awareness and cognition….
Adjunctive Steroid Therapy for Treatment of Pediatric Septic Shock
Septic shock remains the major cause of childhood morbidity and mortality worldwide. Although early sepsis recognition, fluid resuscitation, timely administration of antimicrobials, and vasoactive-inotropic drug infusions are all key to…
Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care
Sedation is a mainstay of therapy for critically ill children. Although necessary in the care of the critically ill child, sedative drugs are associated with adverse effects, such as disruption…
Immunoparalysis in Pediatric Critical Care
Although many forms of critical illness are initiated by a proinflammatory stimulus, a compensatory anti-inflammatory response can occur with systemic inflammation. Immunoparalysis, an important form of acquired immunodeficiency, affects the…
Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure
Adjunctive therapies have been proposed for use in at least 5 inflammation pathobiology phenotypes in pediatric sepsis-induced multiple organ failure. This article discusses host-pathogen interaction prototypes to facilitate understanding of…
