Vaginal Intraepithelial Neoplasia
Vagina Cervix aLow-risk HPV aHigh-risk HPV aLow-risk HPV aHigh-risk HPV LSIL 81 18, 51 6, 11 18 42, 43, 54, 62, 67 56, 66 16, 66 16, 39, 52,…
GYNECOLOGY
Clinical Management of Selected Precancerous Lesions in the Lower Genital Tract
Fig. 14.1 Overview of clinical management for precancerous cervical lesions. WHO World Health Organization, SIL squamous intraepithelial lesion, GIL glandular intraepithelial lesion, CIN1 cervical intraepithelial neoplasia grade 1, CIN2 cervical…
Putative Precursors of Uterine Sarcomas
Fig. 6.1 Cartoon diagram highlights the anatomic site for tumor origin of uterine sarcoma Table 6.1 FIGO staging for uterine sarcomas (2009) [3] Stage Surgical-pathologic findings Leiomyosarcomas and endometrial stromal…
Precursors of High-Grade Serous Carcinoma
Alterations P53 signature Serous tubal intraepithelial lesion (STIL) Serous tubal intraepithelial carcinoma (STIC) High-grade serous carcinoma P53 Mutated (LOH) Mutated Mutated (LOH) Mutated (LOH) BRCA1/BRCA2 Mutated/LOH Mutated/LOH/hypermethylated Genes (FISH) CCNE1…
Precancerous Lesions of Squamous Cell Carcinoma of the Cervix: Squamous Dysplasia
Fig. 13.1 HSIL/CIN3 and atypical mitotic figure. Nuclear atypia extends through the full epithelial thickness without any cytoplasmic maturation in the superficial epithelial layers. Note the nuclear size and nuclear/cytoplasmic…
Precursors of Low-Grade Serous Adenocarcinoma of the Ovary: Pathology and Molecular Pathways
Fig. 2.1 (a) Ovarian cyst with surface involvement by friable papillary excrescences. They appear to cover most of the ovarian cyst surface. (b) The inner lining of the same ovarian…
Clinical Management of Selected Precancerous Lesions of the Uterus, Fallopian Tube, and Ovary
Author # Complex atypical hyperplasia # Endometrial carcinoma Agents used Response rate (%) Median follow-up months (range) Ferenczy (1989) 20 0 MPA 50 5.5 years (2–7 years) Randall (1997) 17…
Peri-urethral Injections
Agent (author) RCT design (N) Follow-up (years) Volume injected (mL)b Dry/improvedc Subjects requiring multiple treatments Durasphere [38] Multicenter Agent (176) 1 Agent: 4.83**** –/66 % 35 % Control (188) Control: 6.23**** –/66 %…
Office Operative Hysteroscopy: Polyp and Submucosal Fibroid Removal
Fig. 9.1 Endometrial polyp occupying >50 of endometrial cavity Fig. 9.2 Submucosal Type I leiomyoma seen in right cornual region of postmenopausal women Physical Examination Careful gynecologic examination should be…
Office Diagnostic Hysteroscopy
Evaluation of abnormal bleeding • Premenopausal anovulatory women • Premenopausal ovulatory women • Postmenopausal bleeding Evaluation of infertility • Routine infertility work-up • Abnormal HSG • Pre-IVF evaluation • Recurrent…
