GYNECOLOGY

Reproductive endocrinology: Neuroendocrinology, Gonadotropins, Sex Steroids, Prostaglandins, Ovulation, Menstruation, and Hormone Assay

Aug 8, 2021 by in GYNECOLOGY Comments Off on Reproductive endocrinology: Neuroendocrinology, Gonadotropins, Sex Steroids, Prostaglandins, Ovulation, Menstruation, and Hormone Assay

Key points • Gonadotropin-releasing hormone (GnRH) analogs are synthesized by substitution of amino acids in the parent molecule at the 6 and 10 positions for GnRH agonists and at the…

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Medical-legal risk management

Aug 8, 2021 by in GYNECOLOGY Comments Off on Medical-legal risk management

Key points • Malpractice is patient injury secondary to failure to exercise that degree of care used by reasonably careful physician of like qualifications • Negligence is failure to extend…

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Evidence-based medicine and clinical epidemiology

Aug 8, 2021 by in GYNECOLOGY Comments Off on Evidence-based medicine and clinical epidemiology

Key points • Evidence-based medicine (EBM) seeks to improve the care of patients and the delivery of care to patients. • Descriptive-observational studies, including cross-sectional studies and case series, help…

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Fertilization and embryogenesis

Aug 8, 2021 by in GYNECOLOGY Comments Off on Fertilization and embryogenesis

Key points • Oocyte meiosis is arrested in prophase I from the fetal period until a luteinizing surge (LH) preceding ovulation. With the LH surge, the oocyte completes meiosis I…

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Reproductive genetics

Aug 8, 2021 by in GYNECOLOGY Comments Off on Reproductive genetics

Key points • Virtually all human diseases have an underlying genetic component. All health care professionals need a basic level of familiarity with genetics and genomics because it is an…

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Anti–severe acute respiratory syndrome coronavirus 2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination

Jul 5, 2021 by in GYNECOLOGY Comments Off on Anti–severe acute respiratory syndrome coronavirus 2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination

Objective In December 2020, 2 lipid nanoparticle-formulated, nucleoside-modified messenger RNA–based vaccines received emergency use authorization by the US Food and Drug Administration, after their trials demonstrated 94% to 95% efficacy…

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Amniotic fluid interleukin 6 and interleukin 8 are superior predictors of fetal lung injury compared with maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model

Jul 5, 2021 by in GYNECOLOGY Comments Off on Amniotic fluid interleukin 6 and interleukin 8 are superior predictors of fetal lung injury compared with maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model

Background Intra-amniotic infection or inflammation is common in early preterm birth and associated with substantial neonatal lung morbidity owing to fetal exposure to proinflammatory cytokines and infectious organisms. Amniotic fluid…

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