Immune-mediated diseases of the central nervous system show wide variability both symptomatically and with respect to underlying pathophysiology. Recognizing aberrant immunologic activity as the cause of neurologic dysfunction requires establishing…
Patients with undiagnosed or rare diseases often remain without a diagnosis for many years. Many are misdiagnosed or treated symptomatically without having an identified underlying disease process. Health care providers…
Although primary immunodeficiencies typically present with recurrent, chronic, or severe infections, autoimmune manifestations frequently accompany these disorders and may be the initial clinical manifestations. The presence of 2 or more…
The scientific process of analysis and deduction is frequently, often subconsciously, used by physicians to develop a differential diagnosis based on patients’ symptoms. Common disorders are most frequently diagnosed in…
Robert M. Kliegman, MD, Editor Brett J. Bordini, MD, Editor The many and rapid advances in new disease discovery and advanced diagnostic testing in pediatric medicine have made it difficult…
Bonita F. Stanton, MD, Consulting Editor As medical students and residents, we quickly gain experience and begin to recognize common disorders in our patients, and gradually, unusual manifestations of common…
PEDIATRIC CLINICS OF NORTH AMERICA www.pediatric.theclinics.com Consulting Editor BONITA F. STANTON February 2017 • Volume 64 • Number 1
Adolescents involved with the juvenile justice system have higher rates of risky sexual behaviors, resulting in high rates of sexually transmitted infections and increased risk of human immunodeficiency virus, early…
Healthy sexual development is important for adolescents with and without disabilities, yet the topic of sexuality is often ignored in the disabled population. Adolescents with mild or moderate degrees of…
Dating violence (also known as adolescent relationship abuse) and sexual violence are prevalent from the middle school years throughout adolescence, peak in young adulthood, and are associated with multiple poor…
