Abstract The endometrium plays host to a variety of alterations in epithelial differentiation, and all of these alterations display a morphologic spectrum from benign changes to those that are malignant….
Abstract Hormonal field effects (non–atypical endometrial hyperplasia) must be distinguished from true precancerous lesions (endometrioid intraepithelial neoplasia [EIN]) because of their differing management. This chapter also presents mimics of precancerous…
Vulva Lentigo L81.4 Seborrheic keratosis L82.1 Fibroepithelial stromal polyp n84.3 Epidermal inclusion cyst n90.7 Lichen sclerosus L90.0 Non-inflammatory conditions N90.89 Inflammatory conditions N76.89 Granulation tissue N76.89 Bartholin gland inflammation N75.8…
Abstract This chapter focuses on the neoplasms that do not fall into the categories of either pure squamous or columnar cell type in the uterine cervix. This most prominent of…
Abstract Endocervical glandular neoplasms comprise a plethora of challenging cytologic patterns and a dichotomy of human papilloma virus (HPV)-positive and HPV-negative tumors. New developments in the HPV-positive neoplasms center on…
Abstract This chapter addresses a spectrum of neoplasms that can be found in the vagina, ranging from the more common, the squamous intraepithelial lesions, to the more obscure. Particularly problematic…
Abstract Vulvovaginal mesenchymal neoplasms and non-neoplastic proliferations are rare. Nonetheless, the spectrum of lesions is wide. A major subset includes tumors preferentially seen in this anatomic location (vulvovaginal stromal tumors)….
Abstract Vulvar squamous neoplasia clinical management depends on the identification of low-grade squamous intraepithelial lesions (exophytic and flat condyloma), high-grade squamous intraepithelial lesions (classic and differentiated vulvar intraepithelial neoplasias [VINs]),…
Abstract The histologic zones of the anal canal include the colorectal zone, anal transitional zone (ATZ), non–hair-bearing squamous mucosa, and perianal skin. The dentate line is the distal end of…
Abstract This chapter addresses a number of nonneoplasitc conditions. They are important mimics of neoplasia, challenges in management, or rare entities that might cause diagnostic confusion. For example, a prolapsed…
