Optimal Oxygenation in Extremely Preterm Infants

Dec 29, 2019 by in PEDIATRICS Comments Off on Optimal Oxygenation in Extremely Preterm Infants

• Targeting appropriate oxygenation in newborn infants can improve outcomes. • Evidence from randomized controlled trials and the corresponding meta-analyses indicate that air vs 100% oxygen for resuscitation of term…

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Newer Strategies for Surfactant Delivery

Dec 29, 2019 by in PEDIATRICS Comments Off on Newer Strategies for Surfactant Delivery

• As fewer preterm infants are managed with an endotracheal tube in early life, the usual conduit for surfactant delivery is lacking. With this approach has come a dilemma regarding…

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Respiratory Control and Apnea in Premature Infants

Dec 29, 2019 by in PEDIATRICS Comments Off on Respiratory Control and Apnea in Premature Infants

• Understanding the physiology of neonatal respiratory control has served as an effective guide to common therapeutic approaches. • Both the acute and longer-term consequences of intermittent hypoxia secondary to…

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Molecular Bases for Lung Development, Injury, and Repair

Dec 29, 2019 by in PEDIATRICS Comments Off on Molecular Bases for Lung Development, Injury, and Repair

• Lung development involves lung bud initiation, branching morphogenesis, saccular formation, alveolar septation, and accompanying vascular development that begins in the embryonic period and continues through fetal and postnatal periods….

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Ventilator-Associated Pneumonia

Dec 29, 2019 by in PEDIATRICS Comments Off on Ventilator-Associated Pneumonia

• Invasive mechanical ventilation of neonates increases their risk of developing bacterial infection of the lower airways and lung parenchyma, which is termed “ventilator-associated pneumonia” (VAP). • VAP is diagnosed…

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Long-Term Pulmonary Outcome of Preterm Infants

Dec 29, 2019 by in PEDIATRICS Comments Off on Long-Term Pulmonary Outcome of Preterm Infants

• Both very and late preterm infants have worse respiratory health in childhood and adolescence. • Very preterm survivors have worse lung function, particularly airway obstruction, in childhood up to…

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