Keywords preeclampsia, eclampsia, HELLP syndrome, differential diagnosis Editors’ comment: The fourth edition of Chesley’s Hypertensive Disorders of Pregnancy is a revision of the previous two multi-authored editions. The fact…
Keywords preeclampsia, pregnancy, obesity, insulin resistance, inflammation, endothelium Editors’ comment: In the early part of the previous century the association between hypertension, increased blood sugar levels and obesity had…
Keywords placentation, preeclampsia, cytotrophoblast, antiangiogenic factors, adhesion molecules Editors’ comment: Without the placenta we would not have preeclampsia (or human civilization either). Thus the recent explosion of research regarding…
Keywords animal models, preeclampsia, placental ischemia, angiogenic factors, genetic mouse models Editors’ comment: Animal models are not mentioned in Chesley’s initial edition, and the word does not appear in…
Keywords angiogenesis, pseudovasculogenesis, soluble fms-like tyrosine kinase-1, soluble endoglin, vascular endothelial growth factor, transforming growth factor beta, placental growth factor, glomerular endotheliosis Editors’ comment: When Chesley wrote his original…
Keywords endothelial cell activation, placental microvesicles, cytokines, antiangiogenic factors, eicosanoids, reactive oxygen species, lipid peroxidation Editors’ comment: It was not until the early 1980s that physicians and scientists gained…
Keywords immunology, innate immune system, T regulatory cells, NK-cells, acute-phase response, trophoblast, HLA, immunoregulation, preeclampsia Editors’ comment: Chesley in his single-authored first edition wrote little regarding immunology and preeclampsia,…
Keywords preeclampsia, genetics, polymorphism, linkage analysis, candidate gene, genomics, polygenic, DNA sequencing Editors’ comment: Recognition that preeclampsia might have a genetic predeliction dates back to late 1800s reports of…
Keywords preeclampsia, epidemiology, incidence, recurrence, risk factors, cardiovascular disease, placenta Editors’ comment: The epidemiology literature relating to hypertension in pregnancy grew substantially since the third edition, much of it…
Keywords introduction, history of preeclampsia, classification schema Leon Chesley’s Hypertensive Disorders in Pregnancy was initially published in 1978. Then, as now, hypertension complicating pregnancy was a major cause of…
