We report a patient with vulvar lichen sclerosus, Langerhans cell histiocytosis (LCH), and later vulvar cancer. In LCH, high amounts of non functional Langerhans cells are present in the affected…
In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article…
Case notes A 68-year-old Chinese woman presented to the emergency department with a pruritic rash, fever, and swelling and tenderness of the left upper extremity and vulva. One day prior…
The article below summarizes a roundtable discussion of a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research….
Objective Maternal diabetes has an adverse impact on embryonic development. We tested the hypothesis that hyperglycemia-induced c-Jun N-terminal kinases (JNK) 1/2 activation mediates inducible nitric oxide synthase (iNOS) induction. Study…
Objective Because the fetal innate immune system is responsive, while still maturing during the preterm period, we hypothesized that the early activation of fetal inflammatory pathways may have an impact…
Objective Levosimendan, a compound that exerts effects on calcium sensitivity and intracellular free calcium, in addition to opening ATP-sensitive K-channels, is widely used in the treatment of heart failure. Because…
Objective High maternal concentrations of thrombin-antithrombin (TAT) complexes have been associated with adverse outcomes. The objective of this study was to evaluate the relationship between TAT in asymptomatic subjects at…
The authors of a research paper describing associations between atrazine exposure and fetal gastroschisis (Waller SA, Paul K, Peterson SE, Hitti J. Agricultural-related chemical exposures, season of conception, and risk…
Objective The objective of this study was to investigate whether the functional rs25531 promoter polymorphism in the serotonin transporter gene is associated with premenstrual dysphoric disorder. Study Design The study…
