Did drug therapy contribute?
Case notes A healthy 68-year-old woman who had had 3 viable offspring and who had undergone hysterectomy had a 3-year history of mild vaginal prolapse. The condition was not bothersome….
Surgical staging in early ovarian carcinoma: Garcia-Soto et al
The article below summarizes a roundtable discussion of a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research….
The pattern of depression screening results across successive pregnancies
Objective Determine whether depression screen results are consistent across successive pregnancies. Study Design The Edinburgh Postnatal Depression Scale was administered in 2 successive pregnancies to 2116 women. A woman was…
Racial differences in gestational age–specific neonatal morbidity: further evidence for different gestational lengths
Objective We sought to quantify the gestational age–specific morbidity of black vs white neonates. Study Design This was a population-based retrospective cohort study of singleton live births in Ohio from…
Delivery of monochorionic twins in the absence of complications: analysis of neonatal outcomes and costs
Objective We sought to estimate the optimal time to deliver uncomplicated monochorionic-diamnionic (MCDA) twins. Study Design Data were retrospectively obtained from twin pregnancies from 2000 through 2009. The gestational week–specific…
Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies
Objective Various tocolytics are used to suppress uterine contractility in patients in preterm labor. Progesterone (P4) is used in patients at high risk for preterm delivery. In this study, we…
Glucocorticoid exposure of sheep at 0.7 to 0.75 gestation augments late-gestation fetal stress responses
Objectives Exposure to glucocorticoid levels inappropriately high for current maturation alters fetal hypothalamo-pituitary-adrenal axis (HPAA) development. In an established fetal sheep model, we determined whether clinical betamethasone doses used to…
Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells
Objective There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis, we investigated the potential for synergistic impact of combined drug…
Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta
Objective Soluble vascular endothelial growth factor receptor–1 (also know as soluble fms-like tyrosine kinase [sFlt]-1) is a key causative factor of preeclampsia. Resveratrol, a plant phytoalexin, has antiinflammatory and cardioprotective…
Association between MTHFR A1298C polymorphism and neural tube defect susceptibility: a metaanalysis
Objective To determine whether 5,10-methylenetetrahydrofolate reductase A1298C polymorphism is associated with neural tube defect susceptibility. Study Design Computerized literature searches of the PubMed, Embase, and Medline database were conducted to…
