Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis

May 26, 2017 by in GYNECOLOGY Comments Off on Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis

Objective This study was aimed at assessing the role of leptin on human myometrium, by studying its receptor expression in pregnant myometrium and the interaction of leptin with inflammation-induced apoptosis….

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Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells

May 26, 2017 by in GYNECOLOGY Comments Off on Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells

Objective The clinical utility of tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) in the treatment of established human malignancies is limited by the development of resistance to TRAIL. We hypothesized that…

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Apoptosis induction and inhibition of hyperplasia formation by 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran in rat uterus

May 26, 2017 by in GYNECOLOGY Comments Off on Apoptosis induction and inhibition of hyperplasia formation by 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran in rat uterus

Objective The study was undertaken to explore the antiproliferative mechanism of action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran (K-1) in estradiol-induced rat uterine hyperplasia. Study Design Adult ovariectomized rats received vehicle or estradiol alone…

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Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women

May 26, 2017 by in GYNECOLOGY Comments Off on Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women

Objective We sought to assess the ability of human epididymis protein 4 (HE4) and CA-125 to distinguish among benign, borderline, and malignant pelvic masses in premenopausal women. Study Design We…

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Surgically managed stage I endometrial cancer in a low-volume center: outcomes and complications in a military residency program

May 26, 2017 by in GYNECOLOGY Comments Off on Surgically managed stage I endometrial cancer in a low-volume center: outcomes and complications in a military residency program

Objective The purpose of this study was to compare operative outcomes and complications for patients with endometrial cancer who underwent staging by laparoscopy vs laparotomy in a low-volume facility. Study…

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Racial and regional differences in age at menopause in the United States: findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study

May 26, 2017 by in GYNECOLOGY Comments Off on Racial and regional differences in age at menopause in the United States: findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study

Objective We sought to examine regional and black-white differences in mean age at self-reported menopause among community-dwelling women in the United States. Study Design This was a cross-sectional survey conducted…

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