Insulin and Diabetes Mellitus
Insulin and Diabetes Mellitus Tania S. Burgert Eda Cengiz William Tamborlane Prior to the advent of insulin therapy, the life expectancy of children with type-1 diabetes mellitus (T1DM) was approximately…
Glucocorticoids
Glucocorticoids Evangelia Charmandari Tomoshige Kino George P. Chrousos Introduction Glucocorticoids regulate a broad spectrum of physiologic functions essential for life and play an important role in the maintenance of basal…
Gastrointestinal Drugs
Gastrointestinal Drugs Catherine O’Brien Jennifer Lowry Kristine Palmer Henry C. Farrar Gregory L. Kearns Laura P. James Introduction Gastrointestinal disorders are common in children and a wide variety of drugs…
Antihypertensive Agents
Antihypertensive Agents Thomas G. Wells Mohammad Ilyas Russell W. Chesney Deborah P. Jones Until 1997, few antihypertensive agents were studied systematically in children, and very few were labeled for use…
Nonsteroidal Anti-Inflammatory Drugs
Nonsteroidal Anti-Inflammatory Drugs Sylvain Chemtob Véronique G. Dorval Inflammation is among the most important tissue responses to injury; it is observed in all acquired disorders as well as genetic conditions…
Local Anesthetic Solutions for Regional Anesthesia in Infants, Children, and Adolescents
Local Anesthetic Solutions for Regional Anesthesia in Infants, Children, and Adolescents Santhanam Suresh Charles J. Coté The use of local anesthetics has increased in the pediatric population because of the…
Analgesic Agents
Analgesic Agents Sinno H.P. Simons Brian J. Anderson Dick Tibboel Introduction It was generally believed that neonates were unable to experience pain (1). The importance of antinociceptive therapy in children,…
Immunosuppressive and Immunomodulatory Drugs
Immunosuppressive and Immunomodulatory Drugs Amrish Jain Rudolph P. Valentini Tej K. Mattoo Scott A. Gruber Introduction Organ transplantation has been performed successfully in infants, children, and adolescents for over four…
Clinical Pharmacology of Antineoplastic Drugs
Clinical Pharmacology of Antineoplastic Drugs Stacey L. Berg Lisa R. Bomgaars David G. Poplack Challenges inherent in administering antineoplastic therapy safely to children are numerous. Among the most critical issues…
