Pharmacologic Treatment Pharmacologic agents used in the management of hyperbilirubinemia can accelerate the normal metabolic pathways for bilirubin clearance, inhibit the enterohepatic circulation of bilirubin, and interfere with bilirubin formation…
Exchange Transfusion Watchko has comprehensively reviewed this subject (538) and Edwards and associates (539) have reviewed the basic indications for, and contraindications to, performing exchange transfusions. A few issues are…
Phototherapy For comprehensive reviews of this subject, the reader is referred to the monograph by Jahrig and associates (479), and to a recent chapter by the author (480). It helps…
Preventing Extreme Hyperbilirubinemia and Kernicterus Most of the cases of kernicterus reported in the last decade did not occur in infants who had ABO or Rh hemolytic disease, but in…
Laboratory Measurements of Bilirubin Total Serum Bilirubin This subject has been reviewed in detail (284,446,447) and addressed, most recently by Lo and associates (282). Although this is one of the…
Prevention, Identification, and Management of Neonatal Hyperbilirubinemia The Approach to a Jaundiced Infant The Institute of Medicine (IOM) issued a report in 2001 that describes a “chasm in health care…
Newer Developments that Affect Our Approach to the Jaundiced Newborn In the last several years, three factors have emerged that have colored our approach to the evaluation and management of…
Pathologic Causes of Jaundice Indirect-reacting Hyperbilirubinemia Table 35-15 lists the causes of pathologic indirect-reacting hyperbilirubinemia in the neonate and Table 35-16 lists the causes of direct-reacting hyperbilirubinemia (cholestatic jaundice). For…
Jaundice in the Healthy Newborn Cord Bilirubin Levels Mean bilirubin levels in cord blood range from 1.4 to 1.9 mg/dL (24 to 32 μmol/L) (235,280,281), and elevated cord bilirubin levels…
