of Drug Interactions: Implications for Treatment With Antiepileptic DrugsMindl M. Messinger and Barry E. Gidal

Jun 21, 2017 by in PEDIATRICS Comments Off on of Drug Interactions: Implications for Treatment With Antiepileptic DrugsMindl M. Messinger and Barry E. Gidal

      Pharmacokinetic interactions, sometimes leading to adverse clinical situations, have long been recognized as an occasionally unavoidable facet of antiepileptic drug (AED) treatment (1,2). Since the mid-1990s, there…

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Epileptic Encephalopathies and De Novo MutationsRima Nabbout

Jun 21, 2017 by in PEDIATRICS Comments Off on Epileptic Encephalopathies and De Novo MutationsRima Nabbout

      INTRODUCTION Infantile epileptic encephalopathies are a group of epilepsies presenting in infancy and characterized by pharmacoresistant seizures, cognitive impairment, and a spectrum of psychiatric and behavioral disorders….

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L. Buck and Howard P. Goodkin

Jun 21, 2017 by in PEDIATRICS Comments Off on L. Buck and Howard P. Goodkin

      The unique mechanism of action of lacosamide, as well as a lack of significant drug interactions, a relatively mild adverse effect profile, and the availability of both…

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and SleepSejal V. Jain

Jun 21, 2017 by in PEDIATRICS Comments Off on and SleepSejal V. Jain

      Sleep and epilepsy are interrelated; worsening of one leads to worsening of the other and a vicious cycle starts. Sleep activates interictal epileptiform discharges (IEDs) and seizures….

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